The association of XRCC1 haplotypes and chromosomal damage levels in peripheral blood lymphocyte among coke-oven workers

Journal Article · Sun May 15 00:00:00 EDT 2005 · Cancer Epidemiology, Biomarkers and Prevention

DOI:https://doi.org/10.1158/1055-9965.EPI-04-0690· OSTI ID:20823745

Leng, Shuguang; Cheng, Juan; Zhang, Linyuan; Niu, Yong; Dai, Yufei; Pan, Zufei; Li, Bin; He, Fengsheng; Zheng, Yuxin ^[1]

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1. Chinese Center for Disease Control and Prevention, Beijing (China). National Institute of Occupational Health and Poison Control

Theoretically, a haplotype has a higher level of heterozygosity than individual single nucleotide polymorphism (SNP) and the association study based on the haplotype may have an increased power for detecting disease associations compared with SNP-based analysis. In this study, we investigated the effects of four haplotype-tagging SNPs (htSNP) and the inferred haplotype pairs of the X-ray cross-complementing group 1 (XRCC1) gene on chromosome damage detected by the cytokinesis-block micronucleus assay. The study included 141 coke-oven workers with exposure to a high level of polycyclic aromatic hydrocarbons and 66 nonexposed controls. The frequencies of total MN and MNed cells were borderline associated with the Arg{sup 194}Trp polymorphism (P = 0.053 and P = 0.050, respectively) but not associated with the Arg{sup 280}His, Arg{sup 399}Gln and Gln{sup 632}Gln polymorphisms among coke-oven workers. Five haplotypes, including CGGG, TGGG, CAGG, CGAG, and CGGA, were inferred based on the four htSNPs of XRCC1 gene. The haplotype CGGG was associated with the decreased frequencies of total MN and MNed cells, and the haplotypes TGGG and CGAG were associated with the increased frequencies of total MN and MNed cells with adjustment for covariates among coke-oven workers. This study showed that the haplotypes derived from htSNPs in the XRCC1 gene were more likely than single SNPs to correlate with the polycyclic aromatic hydrocarbon-induced chromosome damage among coke-oven workers.

• OSTI ID: 20823745
• Journal Information: Cancer Epidemiology, Biomarkers and Prevention, Vol. 14, Issue 5; ISSN 1055-9965
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS
COKE OVENS
COKING PLANTS
BLOOD
GENES
DAMAGE
ENVIRONMENTAL EXPOSURE
PERSONNEL MONITORING
OCCUPATIONAL EXPOSURE
POLYCYCLIC AROMATIC HYDROCARBONS
BIOASSAY
CHROMOSOMES
BIOLOGICAL EFFECTS