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Title: Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase

Abstract

Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity.

Authors:
 [1];  [1];  [1];  [1];  [2];  [2];  [1]
  1. Department of Clinical Microbiology, Faculty of Medical Technology, Mahidol University, Bangkok 10700 (Thailand)
  2. Pure and Applied Biochemistry, Chemical Center, Lund University, P.O. Box 124, 22100 Lund (Sweden)
Publication Date:
OSTI Identifier:
20798849
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 341; Journal Issue: 4; Other Information: DOI: 10.1016/j.bbrc.2006.01.045; PII: S0006-291X(06)00117-3; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANTIBIOTICS; COMPLEXES; MANGANESE; METHIONINE; MICROORGANISMS; RIBOFLAVIN; SCAVENGING; SIMULATION; SUPEROXIDE DISMUTASE; TETRAZOLIUM

Citation Formats

Piacham, Theeraphon, Pure and Applied Biochemistry, Chemical Center, Lund University, P.O. Box 124, 22100 Lund, Isarankura-Na-Ayudhya, Chartchalerm, Nantasenamat, Chanin, Yainoy, Sakda, Lei, Ye, Buelow, Leif, and Prachayasittikul, Virapong. Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase. United States: N. p., 2006. Web. doi:10.1016/j.bbrc.2006.01.045.
Piacham, Theeraphon, Pure and Applied Biochemistry, Chemical Center, Lund University, P.O. Box 124, 22100 Lund, Isarankura-Na-Ayudhya, Chartchalerm, Nantasenamat, Chanin, Yainoy, Sakda, Lei, Ye, Buelow, Leif, & Prachayasittikul, Virapong. Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase. United States. https://doi.org/10.1016/j.bbrc.2006.01.045
Piacham, Theeraphon, Pure and Applied Biochemistry, Chemical Center, Lund University, P.O. Box 124, 22100 Lund, Isarankura-Na-Ayudhya, Chartchalerm, Nantasenamat, Chanin, Yainoy, Sakda, Lei, Ye, Buelow, Leif, and Prachayasittikul, Virapong. 2006. "Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase". United States. https://doi.org/10.1016/j.bbrc.2006.01.045.
@article{osti_20798849,
title = {Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase},
author = {Piacham, Theeraphon and Pure and Applied Biochemistry, Chemical Center, Lund University, P.O. Box 124, 22100 Lund and Isarankura-Na-Ayudhya, Chartchalerm and Nantasenamat, Chanin and Yainoy, Sakda and Lei, Ye and Buelow, Leif and Prachayasittikul, Virapong},
abstractNote = {Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity.},
doi = {10.1016/j.bbrc.2006.01.045},
url = {https://www.osti.gov/biblio/20798849}, journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 4,
volume = 341,
place = {United States},
year = {Fri Mar 24 00:00:00 EST 2006},
month = {Fri Mar 24 00:00:00 EST 2006}
}