Preclinical evaluation of erythropoietin administration in a model of radiation-induced kidney dysfunction
- Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich (Germany)
- Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, The University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA (United States)
- Department of Experimental Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX (United States)
- Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich (Germany)
Purpose: To test whether the clinically available growth factor erythropoietin (EPO) influences radiation-induced normal-tissue damage in a model of kidney dysfunction. Methods: Animal experiments were conducted to test the role of EPO administration in a C3H mouse model of unilateral kidney irradiation with 6, 8, and 10 Gy and to assess the effects of 2 different dose levels of EPO. The kidney function was assessed before radiotherapy, as well as 19, 25, 31, and 37 weeks thereafter by means of {sup 99m}Tc-dimercaptosuccinat scans (static scintigraphy). Results: Concomitant EPO administration significantly increased the degree of radiation-induced kidney dysfunction. A dose of 2,000 IU/kg body weight per injection tended to cause more damage than the lower dose of 500 IU/kg. Conclusion: Administration of growth factors concomitant to radiotherapy might modify the development of kidney dysfunction. Although insulin-like growth factor-1 has previously been shown to protect the kidney, such an effect could not be demonstrated for EPO. The latter agent even increased the development of nephropathy.
- OSTI ID:
- 20793438
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 64, Issue 5; Other Information: DOI: 10.1016/j.ijrobp.2005.11.042; PII: S0360-3016(05)03086-5; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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