Spinal cord gliomas: A multi-institutional retrospective analysis

Journal Article · Wed Mar 15 00:00:00 EST 2006 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2005.0· OSTI ID:20793384

Abdel-Wahab, May ^[1]; Etuk, Blessing ^[1]; Palermo, James ^[2]; Shirato, Hiroki ^[3]; Kresl, John ^[4]; Yapicier, Ozlem ^[5]; Walker, Gail ^[6]; Scheithauer, Bernd W ^[7]; Shaw, Edward ^[2]; Lee, Charles ^[8]; Curran, Walter ^[9]; Thomas, Terry ^[4]; Markoe, Arnold ^[1]

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1. Department of Radiation Oncology, University of Miami, Miami, FL (United States)
2. Department of Radiation Oncology, Wake Forest University School of Medicine, Wake Forest, NC (United States)
3. Department of Radiation Oncology, Hokkaido University, Hokkaido (Japan)
4. Department of Radiation Oncology, Arizona Oncology Services at St Joseph's Hospital and Medical Center, and Cyberknife Center, Barrow Neurologic Institute, Phoenix, AZ (United States)
5. Department of Pathology, Anadolu Health Care System, Kocaeli (Turkey)
6. University of Miami/Sylvester Comprehensive Cancer Center, Division of Biostatistics, Miami, FL (United States)
7. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN (United States)
8. Department of Radiation Oncology, Wayne State University, Detroit, MI (United States)
9. Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (United States)

Purpose: To determine the impact of postoperative radiation therapy (POXRT) on outcome in spinal cord gliomas. Patients and Methods: Data from 242 patients were collected retrospectively from six institutions using a standardized data sheet. Pathology specimens, when available, were centrally reviewed. Results: A total of 183 patients were analyzed: 82 received surgery alone as initial treatment, whereas 101 had surgery and POXRT. Demographic, diagnostic, and treatment factors were analyzed for impact on progression-free (PFS) and overall survival (OS). PFS in ependymoma patients was 74%, 60%, and 35% at 5, 10, 15 years, respectively, and was significantly influenced by treatment type, race, age, tumor grade, and type of surgery on univariate analysis, with age being the only significant factor on multivariate analysis (MVA) (p = 0.01). OS of ependymoma patients was 91%, 84%, and 75% at 5, 10, and 15 years, respectively, and was significantly influenced by both complete resection (p = 0.04) and age (p = 0.03) on MVA. In astrocytomas, PFS was 42%, 29%, and 15% at 5, 10, and 15 years, and was significantly influenced by POXRT in low- and intermediate-grade tumors on MVA (p = 0.02). OS at 5, 10, and 15 years was 59%, 53%, and 32%, respectively, and was significantly influenced by grade on MVA (p < 0.01). Conclusion: Postoperative radiation therapy reduced disease progression in low- and moderate-grade astrocytomas. In ependymomas, complete resection significantly influenced OS.

• OSTI ID: 20793384
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 64, Issue 4; Other Information: DOI: 10.1016/j.ijrobp.2005.09.038; PII: S0360-3016(05)02708-2; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ASTROCYTOMAS
MULTIVARIATE ANALYSIS
PATHOLOGY
PATIENTS
RADIOTHERAPY
SPINAL CORD
SURGERY