Spinal cord gliomas: A multi-institutional retrospective analysis
- Department of Radiation Oncology, University of Miami, Miami, FL (United States)
- Department of Radiation Oncology, Wake Forest University School of Medicine, Wake Forest, NC (United States)
- Department of Radiation Oncology, Hokkaido University, Hokkaido (Japan)
- Department of Radiation Oncology, Arizona Oncology Services at St Joseph's Hospital and Medical Center, and Cyberknife Center, Barrow Neurologic Institute, Phoenix, AZ (United States)
- Department of Pathology, Anadolu Health Care System, Kocaeli (Turkey)
- University of Miami/Sylvester Comprehensive Cancer Center, Division of Biostatistics, Miami, FL (United States)
- Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN (United States)
- Department of Radiation Oncology, Wayne State University, Detroit, MI (United States)
- Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (United States)
Purpose: To determine the impact of postoperative radiation therapy (POXRT) on outcome in spinal cord gliomas. Patients and Methods: Data from 242 patients were collected retrospectively from six institutions using a standardized data sheet. Pathology specimens, when available, were centrally reviewed. Results: A total of 183 patients were analyzed: 82 received surgery alone as initial treatment, whereas 101 had surgery and POXRT. Demographic, diagnostic, and treatment factors were analyzed for impact on progression-free (PFS) and overall survival (OS). PFS in ependymoma patients was 74%, 60%, and 35% at 5, 10, 15 years, respectively, and was significantly influenced by treatment type, race, age, tumor grade, and type of surgery on univariate analysis, with age being the only significant factor on multivariate analysis (MVA) (p = 0.01). OS of ependymoma patients was 91%, 84%, and 75% at 5, 10, and 15 years, respectively, and was significantly influenced by both complete resection (p = 0.04) and age (p = 0.03) on MVA. In astrocytomas, PFS was 42%, 29%, and 15% at 5, 10, and 15 years, and was significantly influenced by POXRT in low- and intermediate-grade tumors on MVA (p = 0.02). OS at 5, 10, and 15 years was 59%, 53%, and 32%, respectively, and was significantly influenced by grade on MVA (p < 0.01). Conclusion: Postoperative radiation therapy reduced disease progression in low- and moderate-grade astrocytomas. In ependymomas, complete resection significantly influenced OS.
- OSTI ID:
- 20793384
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 64, Issue 4; Other Information: DOI: 10.1016/j.ijrobp.2005.09.038; PII: S0360-3016(05)02708-2; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
Similar Records
Long-Term Outcomes of Patients With Spinal Cord Gliomas Treated by Modern Conformal Radiation Techniques
Validation of EORTC Prognostic Factors for Adults With Low-Grade Glioma: A Report Using Intergroup 86-72-51