Reactive Scattering Damage to DNA Components by Hyperthermal Secondary Ions

Journal Article · Fri Jun 23 00:00:00 EDT 2006 · Physical Review Letters

DOI:https://doi.org/10.1103/PhysRevLett.96.243203· OSTI ID:20777295

Zongwu, Deng; Bald, Ilko; Illenberger, Eugen; Huels, Michael A ^[1]

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1. Ion Reaction Laboratory, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4 (Canada)

We have observed reactive scattering damage to fundamental DNA building blocks by the type of hyperthermal secondary ions that are produced along heavy ion tracks in biological media. Reactions include carbon abstraction by N{sup +}, and hydrogen abstraction by O{sup -} and N{sup +}, at collision energies down to 1 eV. Our results show that localized reactive scattering by hyperthermal secondary fragments can lead to important physicochemical damage to DNA in cells irradiated by heavy ions. This suggests a fundamentally different picture of nascent DNA damage induced by heavy ion tracks, compared to conventional (x or {gamma}) radiation tracks.

• OSTI ID: 20777295
• Journal Information: Physical Review Letters, Vol. 96, Issue 24; Other Information: DOI: 10.1103/PhysRevLett.96.243203; (c) 2006 The American Physical Society; Country of input: International Atomic Energy Agency (IAEA); ISSN 0031-9007
• Country of Publication: United States
• Language: English

Related Subjects

74 ATOMIC AND MOLECULAR PHYSICS
CARBON
DNA
DNA DAMAGES
EV RANGE 01-10
HEAVY IONS
HYDROGEN
IRRADIATION
NITROGEN IONS
OXYGEN IONS
PARTICLE TRACKS
SCATTERING