Synthesis and properties of Mg{sub 2}Al layered double hydroxides containing 5-fluorouracil
- Faculty of Chemistry, Institute of Polyoxometalate Chemistry, Northeast Normal University, Number 138, Renmin Street, Changchun City, Jilin Province 130024 (China)
A pharmaceutically active compound, 5-fluorouracil (5-FU) has been firstly intercalated into layered double hydroxide with the restructure method. Powder X-ray diffraction and spectroscopic analysis indicate that 5-FU molecule is stabilized in the host interlayer by electrostatic interaction and intermolecular interaction, and that the orientation of 5-FU is different when changing the pattern of aging treatment or the swelling agent. The release studies show that a rapid release of the drug during the first 40min is followed by a more sustained one, and that the total amount of drug released from hybrid material into the aqueous solution is almost 87% and 74% at pH 4 and 7, respectively. The studies mentioned above suggest that layered double hydroxide might be used as the basis of a tunable drug delivery carrier.
- OSTI ID:
- 20725830
- Journal Information:
- Journal of Solid State Chemistry, Vol. 178, Issue 3; Other Information: DOI: 10.1016/j.jssc.2004.11.005; PII: S0022-4596(04)00602-4; Copyright (c) 2004 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0022-4596
- Country of Publication:
- United States
- Language:
- English
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