Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity

Journal Article · Tue Mar 15 00:00:00 EST 2005 · Virology

DOI:https://doi.org/10.1016/j.virol.2005.01.001· OSTI ID:20637213

Rainio, Eeva-Marja ^[1]; Ahlfors, Helena ^[1]; Carter, Kara L ^[2]; Ruuska, Marja ^[1]; Matikainen, Sampsa ^[1]; Kieff, Elliott ^[2]; Koskinen, Paeivi J ^[1]

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1. Turku Centre for Biotechnology, University of Turku/Abo Akademi University, Tykistoekatu 6B, 20520 Turku (Finland)
2. Department of Medicine and Microbiology, Harvard Medical School, Boston, MA 02115 (United States)

Latent Epstein-Barr virus (EBV) infection is strongly associated with B-cell proliferative diseases such as Burkitt's lymphoma. Here we show that the oncogenic serine/threonine kinases Pim-1 and Pim-2 enhance the activity of the viral transcriptional activator EBNA2. During EBV infection of primary B-lymphocytes, the mRNA expression levels of pim genes, especially of pim-2, are upregulated and remain elevated in latently infected B-cell lines. Thus, EBV-induced upregulation of Pim kinases and Pim-stimulated EBNA2 transcriptional activity may contribute to the ability of EBV to immortalize B-cells and predispose them to malignant growth.

• OSTI ID: 20637213
• Journal Information: Virology, Vol. 333, Issue 2; Other Information: DOI: 10.1016/j.virol.2005.01.001; PII: S0042-6822(05)00006-1; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0042-6822
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
GENES
LYMPHOCYTES
LYMPHOMAS
ONCOGENIC VIRUSES
PHOSPHOTRANSFERASES
SERINE
THREONINE
TRANSCRIPTION