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Title: Neutron capture therapies

In one embodiment there is provided an application of the {sup 10}B(n,{alpha}){sup 7}Li nuclear reaction or other neutron capture reactions for the treatment of rheumatoid arthritis. This application, called Boron Neutron Capture Synovectomy (BNCS), requires substantially altered demands on neutron beam design than for instance treatment of deep seated tumors. Considerations for neutron beam design for the treatment of arthritic joints via BNCS are provided for, and comparisons with the design requirements for Boron Neutron Capture Therapy (BNCT) of tumors are made. In addition, exemplary moderator/reflector assemblies are provided which produce intense, high-quality neutron beams based on (p,n) accelerator-based reactions. In another embodiment there is provided the use of deuteron-based charged particle reactions to be used as sources for epithermal or thermal neutron beams for neutron capture therapies. Many d,n reactions (e.g. using deuterium, tritium or beryllium targets) are very prolific at relatively low deuteron energies.
Authors:
; ;
Publication Date:
OSTI Identifier:
20013228
DOE Contract Number:
FG02-89ER60874
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 2 Nov 1999
Sponsoring Org:
US Department of Energy
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 40 CHEMISTRY; NEUTRON CAPTURE THERAPY; BORON 10; LITHIUM 7; RHEUMATIC DISEASES; DEUTERIUM; RADIATION SOURCES; NEUTRON BEAMS; RADIOPHARMACEUTICALS