Vitamins A{sub 1}, A{sub 2}, and E in minks exposed to polychlorinated biphenyls (Aroclor 1242{reg{underscore}sign}) and copper, via diet based on freshwater or marine fish
Minks (Mustela vison) fed diets based on either freshwater fish or marine fish were exposed to 1 mg of polychlorinated biphenyls (PCBs) (Aroclor 1242) daily for 28 d. To minks on the freshwater diet, copper was also given with or without PCBs. The marine diet included more vitamin A, and E than the freshwater diet. The authors studied how the exposures affected levels of vitamins A{sub 1}, A{sub 2}, and E in liver and adipose tissues and levels of vitamins A{sub 1} and A{sub 2} in plasma. In females and males on the freshwater diet, the hepatic level of vitamin A{sub 2} was decreased because of the PCBs, and in these males the hepatic levels of vitamin E also decreased. Interestingly, with coexposure to PCBs and copper, the vitamin levels were, in general, close to the control values. In adipose tissues also, the PCBs induced significant changes in the concentrations of vitamins A{sub 1} and A{sub 2}. In plasma, vitamins A{sub 1} and A{sub 2} were decreased in all patterns of exposure and on both diets. However, plasma thyroxine was slightly increased, a finding opposite to that reported previously in rodent studies. The results suggest that, in mink, diet greatly modulates the responses to PCBs, which may also differ in males and females. Furthermore, vitamins A{sub 1} and A{sub 2} may not be metabolized equally during PCB administration.
- Research Organization:
- Univ. of Joensuu (FI)
- OSTI ID:
- 20012762
- Journal Information:
- Environmental Toxicology and Chemistry, Vol. 18, Issue 11; Other Information: PBD: Nov 1999; ISSN 0730-7268
- Country of Publication:
- United States
- Language:
- English
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