Molecular cloning of a putative novel human bZIP transcription factor on chromosome 17q22
- Univ. of Oslo (Norway); and others
We have cloned and characterized cDNA clones representing several mRNA isoforms generated by alternative splicing of a single gene localized to chromosome 17q22. Sequence analysis showed that the predicted translational product of the longest open reading frame (2316 nucleotides, 772 amino acids) is related to transcription factors of the basic elucine zipper (bZIP) class. The sequence contained several regions characteristic of transcriptional regulatory domains. A cluster of amino acids flanking the bZIP region on both sides was highly conserved between TCF11 and p45 NF-E2, a subunit of the human globin locus control region-binding protein, NF-E2. These same regions showed remarkable homology to two invertebrate proteins, CNC and skn-1, postulated to regulate embryonic development in Drosophila melanogaster and Caenorhabditis elegans, respectively. 46 refs., 7 figs., 1 tab.
- OSTI ID:
- 186026
- Journal Information:
- Genomics, Vol. 22, Issue 3; Other Information: PBD: Aug 1994
- Country of Publication:
- United States
- Language:
- English
Similar Records
Cloning and mapping of murine Nfe2L1
Isolation of cDNA encoding the human NF-E2 protein