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Title: Collagen gene expression in radiation interstitial pneumonitis

Journal Article · · Journal of Environmental Pathology, Toxicology and Oncology
OSTI ID:171728
; ;  [1]
  1. Institute of Radiation Medicine, Beijing (China); and others

By using type I and type III collagen cDNA probe and cDNA-mRNA in situ hybridization, we observed the changes of rat lung {alpha} 1(I) and {alpha} 1(III) collagen gene expression in radiation interstitial pneumonitis. The results showed that the expressed cell of type I and type III collagen were scattered within the fibroblasts in the thickened interalveolar walls. The type I and type III collagen mRNA content in irradiated animals were higher than those in the controls at 0.5, 1, 2, 3, 6, and 12 months. 10 refs., 4 figs., 1 tab.

OSTI ID:
171728
Journal Information:
Journal of Environmental Pathology, Toxicology and Oncology, Vol. 13, Issue 4; Other Information: PBD: 1994
Country of Publication:
United States
Language:
English

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