DNA polymorphism at the BoLA-DRB3 gene of cattle in relation to resistance and susceptibility to leukemia
- Vavilov Institute of General Genetics, Moscow (Russian Federation); and others
Polymorphism of exon 2 of the BoLA-DRB3 gene was investigated by the PCR-RFLP method in a sample of healthy and leukemia-afflicted Black Pied cattle. Allele variety was studied and allele frequencies were determined in a total sample and in the two groups. Alleles mediating resistance (BoLA-DRB3.2{sup *}11, {sup *}23, and {sup *}28) and susceptibility to leukemia (DRB3.2{sup *}22, {sup *}24, {sup *}16, and {sup *}8) were revealed in Black Pied cattle. The dominant type of inheritance of the disease resistance was confirmed. On the basis of original and published data obtained earlier for Holstein-Friesian cattle, a conclusion was made about the universal character of the spectrum of BoLA-DRB3 alleles providing resistance and susceptibility to leukemia. 18 refs., 1 fig., 3 tabs.
- OSTI ID:
- 160173
- Journal Information:
- Russian Journal of Genetics, Vol. 31, Issue 9; Other Information: PBD: Sep 1995; TN: Translated from Genetika; 31: No. 9, 1294-1299(1995)
- Country of Publication:
- United States
- Language:
- English
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