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Title: Functional One-Dimensional Lipid Bilayers on Carbon Nanotube Templates

We present one-dimensional (1-D) lipid bilayer structures that integrate carbon nanotubes with a key biological environment-phospholipid membrane. Our structures consist of lipid bilayers wrapped around carbon nanotubes modified with a hydrophilic polymer cushion layer. Despite high bilayer curvature, the lipid membrane maintains its fluidity and can sustain repeated damage-recovery cycles. We also present the first evidence of spontaneous insertion of pore-forming proteins into 1-D lipid bilayers. These structures could lead to the development of new classes of biosensors and bioelectronic devices.
Authors:
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Publication Date:
OSTI Identifier:
15020090
Report Number(s):
UCRL-JRNL-205932
Journal ID: ISSN 0002-7863; JACSAT; TRN: US200519%%174
DOE Contract Number:
W-7405-ENG-48
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of the American Chemical Society; Journal Volume: 127; Journal Issue: 20
Research Org:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; CARBON; FUNCTIONALS; LIPIDS; MEMBRANES; NANOTUBES; POLYMERS; PROTEINS