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Title: Biological Applications of Cryogenic Detectors

High energy resolution and broadband efficiency are enabling the use of cryogenic detectors in biological research. Two areas where they have found initial application are X-ray absorption spectroscopy (XAS) and time-of-flight mass spectrometry (TOF-MS). In synchrotron-based fluorescence-detected XAS cryogenic detectors are used to examine the role of metals in biological systems by measuring their oxidation states and ligand symmetries. In time-of-flight mass spectrometry cryogenic detectors increase the sensitivity for biomolecule detection and identification for masses above {approx}50 kDa, and thus enable TOF-MS on large protein complexes or even entire viruses. More recently, cryogenic detectors have been proposed as optical sensors for fluorescence signals from biomarkers. We discuss the potential for cryogenic detectors in biological research, as well as the challenges the technology faces.
Authors:
Publication Date:
OSTI Identifier:
15006280
Report Number(s):
UCRL-CONF-155803
TRN: US200407%%177
DOE Contract Number:
W-7405-ENG-48
Resource Type:
Conference
Resource Relation:
Conference: 10th International Workshop on Low Temperature Detectors, Genoa (IT), 07/07/2003--07/11/2003; Other Information: PBD: 3 Dec 2003
Research Org:
Lawrence Livermore National Lab., CA (US)
Sponsoring Org:
US Department of Energy (US)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ABSORPTION SPECTROSCOPY; CRYOGENICS; DETECTION; EFFICIENCY; ENERGY RESOLUTION; FLUORESCENCE; MASS SPECTROSCOPY; PROTEINS; SENSITIVITY; VALENCE; VIRUSES