Thermogelling Biodegradable Copolymer Aqueous Solutions for Injectable Protein Delivery and Tissue Engineering
This paper reports on the thermogelling, biodegradable polymer formulations based on poly(DL-lactic acid-co-glycolic acid)(polyethylene glycol) graft copolymers for in-vivo biomedical applications. The description includes diabetic control by sustained insulin delivery and cartilage repair by chondrocyte cell delivery. With one injection of the formula, the blood glucose level could be controlled from 5 to 16 days in diabetic rats by varying the polymer composition. Promising cartilage repair was observed using chondrocyte suspension in the thermogelling biodegradable depot.
- Research Organization:
- Pacific Northwest National Lab., Richland, WA (US), Environmental Molecular Sciences Laboratory (US)
- Sponsoring Organization:
- US Department of Energy (US)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 15003802
- Report Number(s):
- PNWD-SA-5654; 1968; TRN: US201015%%128
- Journal Information:
- Biomacromolecules, Vol. 3, Issue 4; Other Information: PBD: 1 Jul 2002
- Country of Publication:
- United States
- Language:
- English
Similar Records
The Effect of Polymer Composition on the Gelation Behavior of PLGA-g-PEG Biodegradable Thermoreversible Gels
Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung
Core–Shell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering
Journal Article
·
Wed Apr 01 00:00:00 EDT 2009
· Journal of Biomedical Materials Research. Part A, 89A(1):248-254
·
OSTI ID:15003802
+1 more
Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung
Journal Article
·
Tue Aug 15 00:00:00 EDT 2006
· Toxicology and Applied Pharmacology
·
OSTI ID:15003802
+5 more
Core–Shell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering
Journal Article
·
Wed Aug 16 00:00:00 EDT 2017
· ACS Macro Letters
·
OSTI ID:15003802
+7 more