Brain SPECT quantitation in clinical diagnosis
- Medical College of Wisconsin, Milwaukee (United States)
Methods to quantitate SPECT data for clinical diagnosis should be chosen so that they take advantage of the lessons learned from PET data. This is particularly important because current SPECT high-resolution brain imaging systems now produce images that are similar in resolution to those generated by the last generation PET equipment (9 mm FWHM). These high-resolution SPECT systems make quantitation of SPECT more problematic than earlier. Methodology validated on low-resolution SPECT systems may no longer be valid for data obtained with the newer SPECT systems. For example, in patients with dementia, the ratio of parietal to cerebellar activity often was studied. However, with new instruments, the cerebellum appears very different: discrete regions are more apparent. The large cerebellar regions usually used with older instrumentation are of an inappropriate size for the new equipment. The normal range for any method of quantitation determined using older equipment probably changes for data obtained with new equipment. It is not surprising that Kim et al. in their simulations demonstrated that because of the finite resolution of imaging systems, the ability to measure pure function is limited, with {open_quotes}anatomy{close_quotes} and {open_quotes}function{close_quotes} coupled in a {open_quotes}complex nonlinear way{close_quotes}. 11 refs.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- OSTI ID:
- 139695
- Report Number(s):
- CONF-9110368-; ON: TI92014827; TRN: 93:003237-013
- Resource Relation:
- Conference: Brain SPECT perfusion imaging: image acquisition, processing, display, and interpretation, Brookhaven, NY (United States), 8-9 Oct 1991; Other Information: PBD: [1991]; Related Information: Is Part Of Brain SPECT perfusion imaging: Image acquisition, processing, display, and interpretation; Weber, D.A.; Woodhead, A.D.; Vivirito, K.J. [eds.] [Brookhaven National Lab., Upton, NY (United States)]; Devous, M.D. Sr. [ed.] [Texas Univ., Dallas, TX (United States). Southwestern Medical Center]; Tikofsky, R.S. [ed.] [Medical Coll. of Wisconsin, Milwaukee, WI (United States)]; PB: 132 p.
- Country of Publication:
- United States
- Language:
- English
Similar Records
Alzheimer disease: Quantitative analysis of I-123-iodoamphetamine SPECT brain imaging
Computer-assisted superimposition of magnetic resonance and high-resolution technetium-99m-HMPAO and thallium-201 SPECT images of the brain