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Title: Total and regional deposition of inhaled aerosols in supine healthy subjects and subjects with mild-to-moderate COPD

Abstract

Despite substantial development of sophisticated subject-specific computational models of aerosol transport and deposition in human lungs, experimental validation of predic- tions from these new models is sparse. We collected aerosol retention and exhalation profiles in seven healthy volunteers and six subjects with mild-to-moderate COPD (FEV1 ¼ 50–80%predicted) in the supine posture. Total deposition was measured during continuous breathing of 1 and 2.9 mm-diameter particles (tidal volume of 1 L, flow rate of 0.3 L/s and 0.75 L/s). Bolus inhalations of 1 mm particles were performed to penetration volumes of 200, 500 and 800 mL (flow rate of 0.5 L/s). Aerosol bolus dispersion (H), deposition, and mode shift (MS) were calculated from these data. There was no significant difference in total deposition between healthy subjects and those with COPD. Total deposition increased with increasing particle size and also with increasing flow rate. Similarly, there was no significant difference in aerosol bolus deposition between subject groups. Yet, the rate of increase in dispersion and of decrease in MS with increasing penetration volume was higher in subjects with COPD than in healthy volunteers (H: 0.79870.205 vs. 0.52770.122 mL/mL, p¼ 0.01; MS: - 0.27170.129 vs. - 0.145 70.076 mL/mL, p¼ 0.05) indicating larger ventilationmore » inhomogeneities (based on H) and increased flow sequencing (based on MS) in the COPD than in the healthy group. In conclusion, in the supine posture, deposition appears to lack sensitivity for assessing the effect of lung morphology and/or ventilation distribution alteration induced by mild-to- moderate lung disease on the fate of inhaled aerosols. However, other parameters such as aerosol bolus dispersion and mode shift may be more sensitive parameters for evaluating models of lungs with moderate disease.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1373006
Report Number(s):
PNNL-SA-122331
Journal ID: ISSN 0021-8502; 400412000
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Journal of Aerosol Science
Additional Journal Information:
Journal Volume: 99; Journal Issue: C; Journal ID: ISSN 0021-8502
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES

Citation Formats

Darquenne, Chantal, Lamm, Wayne J., Fine, Janelle M., Corley, Richard A., and Glenny, Robb W. Total and regional deposition of inhaled aerosols in supine healthy subjects and subjects with mild-to-moderate COPD. United States: N. p., 2016. Web. doi:10.1016/j.jaerosci.2016.01.019.
Darquenne, Chantal, Lamm, Wayne J., Fine, Janelle M., Corley, Richard A., & Glenny, Robb W. Total and regional deposition of inhaled aerosols in supine healthy subjects and subjects with mild-to-moderate COPD. United States. https://doi.org/10.1016/j.jaerosci.2016.01.019
Darquenne, Chantal, Lamm, Wayne J., Fine, Janelle M., Corley, Richard A., and Glenny, Robb W. 2016. "Total and regional deposition of inhaled aerosols in supine healthy subjects and subjects with mild-to-moderate COPD". United States. https://doi.org/10.1016/j.jaerosci.2016.01.019.
@article{osti_1373006,
title = {Total and regional deposition of inhaled aerosols in supine healthy subjects and subjects with mild-to-moderate COPD},
author = {Darquenne, Chantal and Lamm, Wayne J. and Fine, Janelle M. and Corley, Richard A. and Glenny, Robb W.},
abstractNote = {Despite substantial development of sophisticated subject-specific computational models of aerosol transport and deposition in human lungs, experimental validation of predic- tions from these new models is sparse. We collected aerosol retention and exhalation profiles in seven healthy volunteers and six subjects with mild-to-moderate COPD (FEV1 ¼ 50–80%predicted) in the supine posture. Total deposition was measured during continuous breathing of 1 and 2.9 mm-diameter particles (tidal volume of 1 L, flow rate of 0.3 L/s and 0.75 L/s). Bolus inhalations of 1 mm particles were performed to penetration volumes of 200, 500 and 800 mL (flow rate of 0.5 L/s). Aerosol bolus dispersion (H), deposition, and mode shift (MS) were calculated from these data. There was no significant difference in total deposition between healthy subjects and those with COPD. Total deposition increased with increasing particle size and also with increasing flow rate. Similarly, there was no significant difference in aerosol bolus deposition between subject groups. Yet, the rate of increase in dispersion and of decrease in MS with increasing penetration volume was higher in subjects with COPD than in healthy volunteers (H: 0.79870.205 vs. 0.52770.122 mL/mL, p¼ 0.01; MS: - 0.27170.129 vs. - 0.145 70.076 mL/mL, p¼ 0.05) indicating larger ventilation inhomogeneities (based on H) and increased flow sequencing (based on MS) in the COPD than in the healthy group. In conclusion, in the supine posture, deposition appears to lack sensitivity for assessing the effect of lung morphology and/or ventilation distribution alteration induced by mild-to- moderate lung disease on the fate of inhaled aerosols. However, other parameters such as aerosol bolus dispersion and mode shift may be more sensitive parameters for evaluating models of lungs with moderate disease.},
doi = {10.1016/j.jaerosci.2016.01.019},
url = {https://www.osti.gov/biblio/1373006}, journal = {Journal of Aerosol Science},
issn = {0021-8502},
number = C,
volume = 99,
place = {United States},
year = {Thu Sep 01 00:00:00 EDT 2016},
month = {Thu Sep 01 00:00:00 EDT 2016}
}