Atomic-level description of protein–lipid interactions using an accelerated membrane model

Baylon, Javier L.; Vermaas, Josh V.; Muller, Melanie P.; Arcario, Mark J.; Pogorelov, Taras V.; Tajkhorshid, Emad

doi:10.1016/j.bbamem.2016.02.027

Title: Atomic-level description of protein–lipid interactions using an accelerated membrane model

Journal Article · Fri Jul 01 00:00:00 EDT 2016 · Biochimica et Biophysica Acta. Biomembranes

DOI:https://doi.org/10.1016/j.bbamem.2016.02.027· OSTI ID:1367694

Baylon, Javier L.; Vermaas, Josh V.; Muller, Melanie P.; Arcario, Mark J.; Pogorelov, Taras V.; Tajkhorshid, Emad

View Journal Article

Cite

Export

Save

Sponsoring Organization:: USDOE

OSTI ID:: 1367694

Alternate ID(s):: OSTI ID: 1326409

Journal Information:: Biochimica et Biophysica Acta. Biomembranes, Journal Name: Biochimica et Biophysica Acta. Biomembranes Vol. 1858 Journal Issue: 7 PB; ISSN 0005-2736

Publisher:: ElsevierCopyright Statement

Country of Publication:: Netherlands

Language:: English

Citation Metrics:

Cited by: 32 works

Citation information provided by
Web of Science

References (177)

Folding and misfolding of alpha-synuclein on membranes Dikiy, Igor; Eliezer, David Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1818, Issue 4 https://doi.org/10.1016/j.bbamem.2011.09.008	journal	April 2012
Lipid–protein interactions in blood coagulation Zwaal, Robert F. A.; Comfurius, Paul; Bevers, Edouard M. Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, Vol. 1376, Issue 3 https://doi.org/10.1016/S0304-4157(98)00018-5	journal	November 1998
Structural Basis of Integrin Activation by Talin Wegener, Kate L.; Partridge, Anthony W.; Han, Jaewon Cell, Vol. 128, Issue 1 https://doi.org/10.1016/j.cell.2006.10.048	journal	January 2007
Ligand Binding to Cytochrome P450 3A4 in Phospholipid Bilayer Nanodiscs Nath, Abhinav; Grinkova, Yelena V.; Sligar, Stephen G. Journal of Biological Chemistry, Vol. 282, Issue 39 https://doi.org/10.1074/jbc.M703568200	journal	September 2007
Systematic multiscale simulation of membrane protein systems Ayton, Gary S.; Voth, Gregory A. Current Opinion in Structural Biology, Vol. 19, Issue 2 https://doi.org/10.1016/j.sbi.2009.03.001	journal	April 2009
Mapping intact protein isoforms in discovery mode using top-down proteomics Tran, John C.; Zamdborg, Leonid; Ahlf, Dorothy R. Nature, Vol. 480, Issue 7376 https://doi.org/10.1038/nature10575	journal	October 2011
Whole-Body Rocking Motion of a Fusion Peptide in Lipid Bilayers from Size-Dispersed ¹⁵ N NMR Relaxation Lorieau, Justin L.; Louis, John M.; Bax, Ad Journal of the American Chemical Society, Vol. 133, Issue 36 https://doi.org/10.1021/ja2045309	journal	September 2011
Folding is not required for bilayer insertion: Replica exchange simulations of an α-helical peptide with an explicit lipid bilayer Nymeyer, Hugh; Woolf, Thomas B.; Garcia, Angel E. Proteins: Structure, Function, and Bioinformatics, Vol. 59, Issue 4 https://doi.org/10.1002/prot.20460	journal	April 2005
Antiparallel Arrangement of the Helices of Vesicle-Bound α-Synuclein Drescher, Malte; Veldhuis, Gertjan; van Rooijen, Bart D. Journal of the American Chemical Society, Vol. 130, Issue 25 https://doi.org/10.1021/ja801594s	journal	June 2008
Enhancement of Vitamin-K-Dependent Protein Function by Modification of the Î³-Carboxyglutamic Acid Domain Studies of Protein C and Factor VII Nelsestuen, G. Trends in Cardiovascular Medicine, Vol. 9, Issue 6 https://doi.org/10.1016/S1050-1738(99)00024-9	journal	August 1999
Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (Review) Wegener, Kate L.; Campbell, Iain D. Molecular Membrane Biology, Vol. 25, Issue 5 https://doi.org/10.1080/09687680802269886	journal	January 2008
Parkinson's disease Lees, Andrew J.; Hardy, John; Revesz, Tamas The Lancet, Vol. 373, Issue 9680 https://doi.org/10.1016/S0140-6736(09)60492-X	journal	June 2009
Distribution of Amino Acids in a Lipid Bilayer from Computer Simulations MacCallum, Justin L.; Bennett, W. F. Drew; Tieleman, D. Peter Biophysical Journal, Vol. 94, Issue 9 https://doi.org/10.1529/biophysj.107.112805	journal	May 2008
Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles Middleton, Elizabeth R.; Rhoades, Elizabeth Biophysical Journal, Vol. 99, Issue 7 https://doi.org/10.1016/j.bpj.2010.07.056	journal	October 2010
Dynamic, yet structured: The cell membrane three decades after the Singer–Nicolson model Vereb, G.; Szöllősi, J.; Matkó, J. Proceedings of the National Academy of Sciences, Vol. 100, Issue 14 https://doi.org/10.1073/pnas.1332550100	journal	June 2003
Mutagenesis of the γ-Carboxyglutamic Acid Domain of Human Factor VII to Generate Maximum Enhancement of the Membrane Contact Site Harvey, Stephen B.; Stone, Matthew D.; Martinez, Michael B. Journal of Biological Chemistry, Vol. 278, Issue 10 https://doi.org/10.1074/jbc.M211629200	journal	March 2003
-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro Burre, J.; Sharma, M.; Tsetsenis, T. Science, Vol. 329, Issue 5999 https://doi.org/10.1126/science.1195227	journal	August 2010
The interactions of peripheral membrane proteins with biological membranes Whited, A. M.; Johs, A. Chemistry and Physics of Lipids, Vol. 192 https://doi.org/10.1016/j.chemphyslip.2015.07.015	journal	November 2015
The Cation-π Box Is a Specific Phosphatidylcholine Membrane Targeting Motif Cheng, Jiongjia; Goldstein, Rebecca; Gershenson, Anne Journal of Biological Chemistry, Vol. 288, Issue 21 https://doi.org/10.1074/jbc.M113.466532	journal	April 2013
A host-guest system to study structure-function relationships of membrane fusion peptides Han, X.; Tamm, L. K. Proceedings of the National Academy of Sciences, Vol. 97, Issue 24 https://doi.org/10.1073/pnas.230212097	journal	November 2000
Membrane Interaction of the Factor VIIIa Discoidin Domains in Atomistic Detail Madsen, Jesper J.; Ohkubo, Y. Zenmei; Peters, Günther H. Biochemistry, Vol. 54, Issue 39 https://doi.org/10.1021/acs.biochem.5b00417	journal	September 2015
Membrane lipids: where they are and how they behave van Meer, Gerrit; Voelker, Dennis R.; Feigenson, Gerald W. Nature Reviews Molecular Cell Biology, Vol. 9, Issue 2 https://doi.org/10.1038/nrm2330	journal	February 2008
Synaptotagmin’s Role in Neurotransmitter Release Likely Involves Ca 2+ -induced Conformational Transition Wu, Zhe; Schulten, Klaus Biophysical Journal, Vol. 107, Issue 5 https://doi.org/10.1016/j.bpj.2014.07.041	journal	September 2014
The Tail of Integrins, Talin, and Kindlins Moser, M.; Legate, K. R.; Zent, R. Science, Vol. 324, Issue 5929 https://doi.org/10.1126/science.1163865	journal	May 2009
Simulations of Phospholipids Using a Coarse Grain Model Shelley, John C.; Shelley, Mee Y.; Reeder, Robert C. The Journal of Physical Chemistry B, Vol. 105, Issue 40 https://doi.org/10.1021/jp011637n	journal	October 2001
The MARTINI Coarse-Grained Force Field: Extension to Proteins Monticelli, Luca; Kandasamy, Senthil K.; Periole, Xavier Journal of Chemical Theory and Computation, Vol. 4, Issue 5 https://doi.org/10.1021/ct700324x	journal	April 2008
Characterizing the Membrane-Bound State of Cytochrome P450 3A4: Structure, Depth of Insertion, and Orientation Baylon, Javier L.; Lenov, Ivan L.; Sligar, Stephen G. Journal of the American Chemical Society, Vol. 135, Issue 23 https://doi.org/10.1021/ja4003525	journal	May 2013
Structural Determinants of Integrin Recognition by Talin Garcı́a-Alvarez, Begoña; de Pereda, José M.; Calderwood, David A. Molecular Cell, Vol. 11, Issue 1 https://doi.org/10.1016/S1097-2765(02)00823-7	journal	January 2003
The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation Calderwood, David A.; Zent, Roy; Grant, Richard Journal of Biological Chemistry, Vol. 274, Issue 40 https://doi.org/10.1074/jbc.274.40.28071	journal	October 1999
Platelet integrin ? _IIb ? ₃ : activation mechanisms Ma, Y. -Q.; Qin, J.; Plow, E. F. Journal of Thrombosis and Haemostasis, Vol. 5, Issue 7 https://doi.org/10.1111/j.1538-7836.2007.02537.x	journal	July 2007
Redox Potential Tuning through Differential Quinone Binding in the Photosynthetic Reaction Center of Rhodobacter sphaeroides Vermaas, Josh V.; Taguchi, Alexander T.; Dikanov, Sergei A. Biochemistry, Vol. 54, Issue 12 https://doi.org/10.1021/acs.biochem.5b00033	journal	March 2015
High Resolution Structures of p-Aminobenzamidine- and Benzamidine-VIIa/Soluble Tissue Factor Bajaj, S. Paul; Schmidt, Amy E.; Agah, Sayeh Journal of Biological Chemistry, Vol. 281, Issue 34 https://doi.org/10.1074/jbc.M509971200	journal	August 2006
Integrin activation by talin Ratnikov, B. I.; Partridge, A. W.; Ginsberg, M. H. Journal of Thrombosis and Haemostasis, Vol. 3, Issue 8 https://doi.org/10.1111/j.1538-7836.2005.01362.x	journal	August 2005
Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins Kim, M. Science, Vol. 301, Issue 5640 https://doi.org/10.1126/science.1084174	journal	September 2003
A Designed Inhibitor of a CLC Antiporter Blocks Function through a Unique Binding Mode Howery, Andrew E.; Elvington, Shelley; Abraham, Sherwin J. Chemistry & Biology, Vol. 19, Issue 11 https://doi.org/10.1016/j.chembiol.2012.09.017	journal	November 2012
Peptide-specific antibodies localize the major lipid binding sites of talin dimers to oppositely arranged N-terminal 47 kDa subdomains ¹ Isenberg, Gerhard; Goldmann, Wolfgang H. FEBS Letters, Vol. 426, Issue 2 https://doi.org/10.1016/S0014-5793(98)00336-6	journal	April 1998
Membrane Docking of the Synaptotagmin 7 C2A Domain: Electron Paramagnetic Resonance Measurements Show Contributions from Two Membrane Binding Loops Osterberg, J. Ryan; Chon, Nara Lee; Boo, Arthur Biochemistry, Vol. 54, Issue 37 https://doi.org/10.1021/acs.biochem.5b00421	journal	September 2015
Multiscale Molecular Dynamics Simulations of Membrane Proteins Khalid, Syma; Bond, Peter J. Biomolecular Simulations. Methods in Molecular Biology https://doi.org/10.1007/978-1-62703-017-5_25	book	August 2012
Membrane recognition by phospholipid-binding domains Lemmon, Mark A. Nature Reviews Molecular Cell Biology, Vol. 9, Issue 2 https://doi.org/10.1038/nrm2328	journal	February 2008
Directed Self-Assembly of Monodisperse Phospholipid Bilayer Nanodiscs with Controlled Size Denisov, I. G.; Grinkova, Y. V.; Lazarides, A. A. Journal of the American Chemical Society, Vol. 126, Issue 11 https://doi.org/10.1021/ja0393574	journal	March 2004
Intrinsically Disordered p53 Extreme C-Terminus Binds to S100B(ββ) through “Fly-Casting” Chen, Jianhan Journal of the American Chemical Society, Vol. 131, Issue 6 https://doi.org/10.1021/ja809547p	journal	February 2009
Predictive energy landscapes for folding membrane protein assemblies Truong, Ha H.; Kim, Bobby L.; Schafer, Nicholas P. The Journal of Chemical Physics, Vol. 143, Issue 24 https://doi.org/10.1063/1.4929598	journal	December 2015
Multiscale simulations suggest a mechanism for integrin inside-out activation Kalli, A. C.; Campbell, I. D.; Sansom, M. S. P. Proceedings of the National Academy of Sciences, Vol. 108, Issue 29 https://doi.org/10.1073/pnas.1104505108	journal	July 2011
Ca2+-independent Binding of Anionic Phospholipids by Phospholipase C δ1 EF-hand Domain Cai, Jingfei; Guo, Su; Lomasney, Jon W. Journal of Biological Chemistry, Vol. 288, Issue 52 https://doi.org/10.1074/jbc.M113.512186	journal	December 2013
Designs for life: protocell models in the laboratory Dzieciol, Alicja J.; Mann, Stephen Chem. Soc. Rev., Vol. 41, Issue 1 https://doi.org/10.1039/C1CS15211D	journal	January 2012
Dynamics in atomistic simulations of phospholipid membranes: Nuclear magnetic resonance relaxation rates and lateral diffusion Wohlert, Jakob; Edholm, Olle The Journal of Chemical Physics, Vol. 125, Issue 20 https://doi.org/10.1063/1.2393240	journal	November 2006
The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain Elliott, Paul R.; Goult, Benjamin T.; Kopp, Petra M. Structure, Vol. 18, Issue 10 https://doi.org/10.1016/j.str.2010.07.011	journal	October 2010
Accelerating Membrane Insertion of Peripheral Proteins with a Novel Membrane Mimetic Model Ohkubo, Y. Zenmei; Pogorelov, Taras V.; Arcario, Mark J. Biophysical Journal, Vol. 102, Issue 9 https://doi.org/10.1016/j.bpj.2012.03.015	journal	May 2012
Perspective on the Martini model Marrink, Siewert J.; Tieleman, D. Peter Chemical Society Reviews, Vol. 42, Issue 16 https://doi.org/10.1039/c3cs60093a	journal	January 2013
Phospholipid Binding of Synthetic Talin Peptides Provides Evidence for an Intrinsic Membrane Anchor of Talin Seelig, Anna; Blatter, Xiaochun Li; Frentzel, Adrian Journal of Biological Chemistry, Vol. 275, Issue 24 https://doi.org/10.1074/jbc.M002264200	journal	June 2000
The Structure of the Talin/Integrin Complex at a Lipid Bilayer: An NMR and MD Simulation Study Kalli, Antreas C.; Wegener, Kate L.; Goult, Benjamin T. Structure, Vol. 18, Issue 10 https://doi.org/10.1016/j.str.2010.07.012	journal	October 2010
Surface-Tension Replica-Exchange Molecular Dynamics Method for Enhanced Sampling of Biological Membrane Systems Mori, Takaharu; Jung, Jaewoon; Sugita, Yuji Journal of Chemical Theory and Computation, Vol. 9, Issue 12 https://doi.org/10.1021/ct400445k	journal	November 2013
Direct Evidence of Coexisting Horseshoe and Extended Helix Conformations of Membrane-Bound Alpha-Synuclein Robotta, Marta; Braun, Patrick; van Rooijen, Bart ChemPhysChem, Vol. 12, Issue 2 https://doi.org/10.1002/cphc.201000815	journal	December 2010
Docking Phospholipase A2 on Membranes Using Electrostatic Potential-Modulated Spin Relaxation Magnetic Resonance Lin, Y. Science, Vol. 279, Issue 5358 https://doi.org/10.1126/science.279.5358.1925	journal	March 1998
Mammalian Microsomal Cytochrome P450 Monooxygenase Williams, Pamela A.; Cosme, Jose; Sridhar, Vandana Molecular Cell, Vol. 5, Issue 1 https://doi.org/10.1016/S1097-2765(00)80408-6	journal	January 2000
Structure of membrane-bound -synuclein from site-directed spin labeling and computational refinement Jao, C. C.; Hegde, B. G.; Chen, J. Proceedings of the National Academy of Sciences, Vol. 105, Issue 50 https://doi.org/10.1073/pnas.0807826105	journal	December 2008
Quantitative Modeling of Membrane Deformations by Multihelical Membrane Proteins: Application to G-Protein Coupled Receptors Mondal, Sayan; Khelashvili, George; Shan, Jufang Biophysical Journal, Vol. 101, Issue 9 https://doi.org/10.1016/j.bpj.2011.09.037	journal	November 2011
Drug—target network Yıldırım, Muhammed A.; Goh, Kwang-Il; Cusick, Michael E. Nature Biotechnology, Vol. 25, Issue 10 https://doi.org/10.1038/nbt1338	journal	October 2007
Direct in vivo interaction of the antibiotic primycin with the plasma membrane of Candida albicans: An EPR study Virág, Eszter; Belagyi, Joseph; Gazdag, Zoltán Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1818, Issue 1 https://doi.org/10.1016/j.bbamem.2011.09.020	journal	January 2012
Implicit Modeling of Membranes Grossfield, Alan Current Topics in Membranes https://doi.org/10.1016/S1063-5823(08)00005-7	book	January 2008
Sequence-Dependent Interaction of β-Peptides with Membranes Mondal, Jagannath; Zhu, Xiao; Cui, Qiang The Journal of Physical Chemistry B, Vol. 114, Issue 42 https://doi.org/10.1021/jp1070242	journal	October 2010
Coarse Grained Model for Semiquantitative Lipid Simulations Marrink, Siewert J.; de Vries, Alex H.; Mark, Alan E. The Journal of Physical Chemistry B, Vol. 108, Issue 2 https://doi.org/10.1021/jp036508g	journal	January 2004
H+-induced Membrane Insertion of Influenza Virus Hemagglutinin Involves the HA2 Amino-terminal Fusion Peptide but Not the Coiled Coil Region Durrer, Peter; Galli, Carmela; Hoenke, Stefan Journal of Biological Chemistry, Vol. 271, Issue 23 https://doi.org/10.1074/jbc.271.23.13417	journal	June 1996
Mechanism of Drug–Drug Interactions Mediated by Human Cytochrome P450 CYP3A4 Monomer Denisov, Ilia G.; Grinkova, Yelena V.; Baylon, Javier L. Biochemistry, Vol. 54, Issue 13 https://doi.org/10.1021/acs.biochem.5b00079	journal	March 2015
The power of coarse graining in biomolecular simulations: The power of coarse graining in biomolecular simulations Ingólfsson, Helgi I.; Lopez, Cesar A.; Uusitalo, Jaakko J. Wiley Interdisciplinary Reviews: Computational Molecular Science, Vol. 4, Issue 3 https://doi.org/10.1002/wcms.1169	journal	August 2013
α-Synuclein Membrane Interactions and Lipid Specificity Jo, Euijung; McLaurin, JoAnne; Yip, Christopher M. Journal of Biological Chemistry, Vol. 275, Issue 44 https://doi.org/10.1074/jbc.M004345200	journal	November 2000
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction Anthis, Nicholas J.; Wegener, Kate L.; Ye, Feng The EMBO Journal, Vol. 28, Issue 22 https://doi.org/10.1038/emboj.2009.287	journal	October 2009
Definition of a Molecular Pathway Mediating -Synuclein Neurotoxicity Burre, J.; Sharma, M.; Sudhof, T. C. Journal of Neuroscience, Vol. 35, Issue 13 https://doi.org/10.1523/JNEUROSCI.4650-14.2015	journal	April 2015
Defining Specific Lipid Binding Sites for a Peripheral Membrane Protein in Situ Using Subtesla Field-cycling NMR Pu, Mingming; Orr, Andrew; Redfield, Alfred G. Journal of Biological Chemistry, Vol. 285, Issue 35 https://doi.org/10.1074/jbc.M110.123083	journal	August 2010
A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion Song, Xianqiang; Yang, Jun; Hirbawi, Jamila Cell Research, Vol. 22, Issue 11 https://doi.org/10.1038/cr.2012.97	journal	June 2012
Contribution of Membrane Elastic Energy to Rhodopsin Function Soubias, Olivier; Teague, Walter E.; Hines, Kirk G. Biophysical Journal, Vol. 99, Issue 3 https://doi.org/10.1016/j.bpj.2010.04.068	journal	August 2010
New Insights into the Spring-Loaded Conformational Change of Influenza Virus Hemagglutinin Gruenke, Jennifer A.; Armstrong, R. Todd; Newcomb, William W. Journal of Virology, Vol. 76, Issue 9 https://doi.org/10.1128/JVI.76.9.4456-4466.2002	journal	May 2002
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders Miller, Walter L.; Auchus, Richard J. Endocrine Reviews, Vol. 32, Issue 1 https://doi.org/10.1210/er.2010-0013	journal	February 2011
Dynamical motions of lipids and a finite size effect in simulations of bilayers Klauda, Jeffery B.; Brooks, Bernard R.; Pastor, Richard W. The Journal of Chemical Physics, Vol. 125, Issue 14 https://doi.org/10.1063/1.2354486	journal	October 2006
A Combinatorial NMR and EPR Approach for Evaluating the Structural Ensemble of Partially Folded Proteins Rao, Jampani Nageswara; Jao, Christine C.; Hegde, Balachandra G. Journal of the American Chemical Society, Vol. 132, Issue 25 https://doi.org/10.1021/ja100646t	journal	June 2010
Prediction of the human membrane proteome Fagerberg, Linn; Jonasson, Kalle; von Heijne, Gunnar PROTEOMICS, Vol. 10, Issue 6 https://doi.org/10.1002/pmic.200900258	journal	February 2010
A Highly Tilted Membrane Configuration for the Prefusion State of Synaptobrevin Blanchard, Andrew E.; Arcario, Mark J.; Schulten, Klaus Biophysical Journal, Vol. 107, Issue 9 https://doi.org/10.1016/j.bpj.2014.09.013	journal	November 2014
A Microscopic View of Phospholipid Insertion into Biological Membranes Vermaas, Josh V.; Tajkhorshid, Emad The Journal of Physical Chemistry B, Vol. 118, Issue 7 https://doi.org/10.1021/jp409854w	journal	December 2013
Integrins Hynes, Richard O. Cell, Vol. 110, Issue 6 https://doi.org/10.1016/S0092-8674(02)00971-6	journal	September 2002
Molecular Determinants of Phospholipid Synergy in Blood Clotting Tavoosi, Narjes; Davis-Harrison, Rebecca L.; Pogorelov, Taras V. Journal of Biological Chemistry, Vol. 286, Issue 26 https://doi.org/10.1074/jbc.M111.251769	journal	May 2011
Solvation Energies of Amino Acid Side Chains and Backbone in a Family of Host−Guest Pentapeptides ^† Wimley, William C.; Creamer, Trevor P.; White, Stephen H. Biochemistry, Vol. 35, Issue 16 https://doi.org/10.1021/bi9600153	journal	January 1996
The Fluid Mosaic Model of the Structure of Cell Membranes Singer, S. J.; Nicolson, G. L. Science, Vol. 175, Issue 4023 https://doi.org/10.1126/science.175.4023.720	journal	February 1972
CHARMM-GUI HMMM Builder for Membrane Simulations with the Highly Mobile Membrane-Mimetic Model Qi, Yifei; Cheng, Xi; Lee, Jumin Biophysical Journal, Vol. 109, Issue 10 https://doi.org/10.1016/j.bpj.2015.10.008	journal	November 2015
Capturing Spontaneous Membrane Insertion of the Influenza Virus Hemagglutinin Fusion Peptide Baylon, Javier L.; Tajkhorshid, Emad The Journal of Physical Chemistry B, Vol. 119, Issue 25 https://doi.org/10.1021/acs.jpcb.5b02135	journal	June 2015
Signalling ballet in space and time Kholodenko, Boris N.; Hancock, John F.; Kolch, Walter Nature Reviews Molecular Cell Biology, Vol. 11, Issue 6 https://doi.org/10.1038/nrm2901	journal	June 2010
Extensive Small-Angle X-ray Scattering Studies of Blood Coagulation Factor VIIa Reveal Interdomain Flexibility Mosbæk, Charlotte Rode; Nolan, David; Persson, Egon Biochemistry, Vol. 49, Issue 45 https://doi.org/10.1021/bi1011207	journal	November 2010
Membrane curvature modulation of protein activity determined by NMR Epand, Richard M.; D'Souza, Kenneth; Berno, Bob Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1848, Issue 1 https://doi.org/10.1016/j.bbamem.2014.05.004	journal	January 2015
Substrate Routes to the Buried Active Site May Vary among Cytochromes P450: Mutagenesis of the F−G Region in P450 2B1 ^† Scott, Emily E.; He, You Qun; Halpert, James R. Chemical Research in Toxicology, Vol. 15, Issue 11 https://doi.org/10.1021/tx020057u	journal	November 2002
Incorporation of charged residues in the CYP2J2 F-G loop disrupts CYP2J2–lipid bilayer interactions McDougle, Daniel R.; Baylon, Javier L.; Meling, Daryl D. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1848, Issue 10 https://doi.org/10.1016/j.bbamem.2015.07.015	journal	October 2015
α-Synuclein Populates Both Elongated and Broken Helix States on Small Unilamellar Vesicles Lokappa, Sowmya Bekshe; Ulmer, Tobias S. Journal of Biological Chemistry, Vol. 286, Issue 24 https://doi.org/10.1074/jbc.M111.224055	journal	April 2011
Effective energy function for proteins in lipid membranes Lazaridis, Themis Proteins: Structure, Function, and Genetics, Vol. 52, Issue 2 https://doi.org/10.1002/prot.10410	journal	June 2003
Alpha-Synuclein Binds to the Inner Membrane of Mitochondria in an α-Helical Conformation Robotta, Marta; Gerding, Hanne R.; Vogel, Antonia ChemBioChem, Vol. 15, Issue 17 https://doi.org/10.1002/cbic.201402281	journal	September 2014
Spectrin Domains Lose Cooperativity in Forced Unfolding Randles, Lucy G.; Rounsevell, Ross W. S.; Clarke, Jane Biophysical Journal, Vol. 92, Issue 2 https://doi.org/10.1529/biophysj.106.093690	journal	January 2007
SLIM: An improved generalized Born implicit membrane model Setzler, Julia; Seith, Carolin; Brieg, Martin Journal of Computational Chemistry, Vol. 35, Issue 28 https://doi.org/10.1002/jcc.23717	journal	September 2014
pH-triggered, activated-state conformations of the influenza hemagglutinin fusion peptide revealed by NMR Lorieau, J. L.; Louis, J. M.; Schwieters, C. D. Proceedings of the National Academy of Sciences, Vol. 109, Issue 49 https://doi.org/10.1073/pnas.1213801109	journal	November 2012
Balancing Solvation and Intramolecular Interactions: Toward a Consistent Generalized Born Force Field Chen, Jianhan; Im, Wonpil; Brooks, Charles L. Journal of the American Chemical Society, Vol. 128, Issue 11 https://doi.org/10.1021/ja057216r	journal	March 2006
Membrane-Protein Interactions in Cell Signaling and Membrane Trafficking Cho, Wonhwa; Stahelin, Robert V. Annual Review of Biophysics and Biomolecular Structure, Vol. 34, Issue 1 https://doi.org/10.1146/annurev.biophys.33.110502.133337	journal	June 2005
Functional role of cardiolipin in mitochondrial bioenergetics Paradies, Giuseppe; Paradies, Valeria; De Benedictis, Valentina Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1837, Issue 4 https://doi.org/10.1016/j.bbabio.2013.10.006	journal	April 2014
Membrane-Induced Structural Rearrangement and Identification of a Novel Membrane Anchor in Talin F2F3 Arcario, Mark J.; Tajkhorshid, Emad Biophysical Journal, Vol. 107, Issue 9 https://doi.org/10.1016/j.bpj.2014.09.022	journal	November 2014
C2 Domain of Protein Kinase Cα: Elucidation of the Membrane Docking Surface by Site-Directed Fluorescence and Spin Labeling ^† Kohout, Susy C.; Corbalán-García, Senena; Gómez-Fernández, Juan C. Biochemistry, Vol. 42, Issue 5 https://doi.org/10.1021/bi026596f	journal	February 2003
Multiscale coarse graining of liquid-state systems Izvekov, Sergei; Voth, Gregory A. The Journal of Chemical Physics, Vol. 123, Issue 13 https://doi.org/10.1063/1.2038787	journal	October 2005
Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis Lechtenberg, Bernhard C.; Murray-Rust, Thomas A.; Johnson, Daniel J. D. Blood, Vol. 122, Issue 16 https://doi.org/10.1182/blood-2013-06-511733	journal	October 2013
Neutron Reflectometry Studies Define Prion Protein N-terminal Peptide Membrane Binding Le Brun, Anton P.; Haigh, Cathryn L.; Drew, Simon C. Biophysical Journal, Vol. 107, Issue 10 https://doi.org/10.1016/j.bpj.2014.09.027	journal	November 2014
Hierarchical coarse-graining strategy for protein-membrane systems to access mesoscopic scales Ayton, Gary S.; Lyman, Edward; Voth, Gregory A. Faraday Discuss., Vol. 144 https://doi.org/10.1039/B901996K	journal	January 2010
CYTOCHROME P-450 3A4: Regulation and Role in Drug Metabolism Guengerich, F. Peter Annual Review of Pharmacology and Toxicology, Vol. 39, Issue 1 https://doi.org/10.1146/annurev.pharmtox.39.1.1	journal	April 1999
α-Synuclein Induces Both Positive Mean Curvature and Negative Gaussian Curvature in Membranes Braun, Anthony R.; Sevcsik, Eva; Chin, Pamela Journal of the American Chemical Society, Vol. 134, Issue 5 https://doi.org/10.1021/ja208316h	journal	January 2012
Viral membrane fusion Harrison, Stephen C. Virology, Vol. 479-480 https://doi.org/10.1016/j.virol.2015.03.043	journal	May 2015
pH-dependent Self-association of Influenza Hemagglutinin Fusion Peptides in Lipid Bilayers Han, Xing; Tamm, Lukas K. Journal of Molecular Biology, Vol. 304, Issue 5 https://doi.org/10.1006/jmbi.2000.4251	journal	December 2000
Partitioning of Amino Acids into a Model Membrane: Capturing the Interface Pogorelov, Taras V.; Vermaas, Josh V.; Arcario, Mark J. The Journal of Physical Chemistry B, Vol. 118, Issue 6 https://doi.org/10.1021/jp4089113	journal	January 2014
Lipids as Universal Biomarkers of Extraterrestrial Life Georgiou, Christos D.; Deamer, David W. Astrobiology, Vol. 14, Issue 6 https://doi.org/10.1089/ast.2013.1134	journal	June 2014
Membrane topology of the mammalian P450 cytochromes Black, Shaun D. The FASEB Journal, Vol. 6, Issue 2 https://doi.org/10.1096/fasebj.6.2.1537456	journal	January 1992
An Implicit Membrane Generalized Born Theory for the Study of Structure, Stability, and Interactions of Membrane Proteins Im, Wonpil; Feig, Michael; Brooks, Charles L. Biophysical Journal, Vol. 85, Issue 5 https://doi.org/10.1016/S0006-3495(03)74712-2	journal	November 2003
Quantifying Transient Interactions between Bacillus Phosphatidylinositol-Specific Phospholipase-C and Phosphatidylcholine-Rich Vesicles Yang, Boqian; Pu, Mingming; Khan, Hanif M. Journal of the American Chemical Society, Vol. 137, Issue 1 https://doi.org/10.1021/ja508631n	journal	December 2014
Capturing Spontaneous Partitioning of Peripheral Proteins Using a Biphasic Membrane-Mimetic Model Arcario, Mark J.; Ohkubo, Y. Zenmei; Tajkhorshid, Emad The Journal of Physical Chemistry B, Vol. 115, Issue 21 https://doi.org/10.1021/jp109631y	journal	June 2011
Conditional Peripheral Membrane Proteins: Facing up to Limited Specificity Moravcevic, Katarina; Oxley, Camilla L.; Lemmon, Mark A. Structure, Vol. 20, Issue 1 https://doi.org/10.1016/j.str.2011.11.012	journal	January 2012
Structural basis of membrane binding by Gla domains of vitamin K–dependent proteins Huang, Mingdong; Rigby, Alan C.; Morelli, Xavier Nature Structural & Molecular Biology, Vol. 10, Issue 9 https://doi.org/10.1038/nsb971	journal	August 2003
Cytochromes P450 and metabolism of xenobiotics Anzenbacher, P.; Anzenbacherová, E. Cellular and Molecular Life Sciences, Vol. 58, Issue 5 https://doi.org/10.1007/PL00000897	journal	May 2001
The final steps of integrin activation: the end game Shattil, Sanford J.; Kim, Chungho; Ginsberg, Mark H. Nature Reviews Molecular Cell Biology, Vol. 11, Issue 4 https://doi.org/10.1038/nrm2871	journal	April 2010
The talin–tail interaction places integrin activation on FERM ground Campbell, Iain D.; Ginsberg, Mark H. Trends in Biochemical Sciences, Vol. 29, Issue 8 https://doi.org/10.1016/j.tibs.2004.06.005	journal	August 2004
α-Synuclein Binds Large Unilamellar Vesicles as an Extended Helix ^† Trexler, Adam J.; Rhoades, Elizabeth Biochemistry, Vol. 48, Issue 11 https://doi.org/10.1021/bi900114z	journal	March 2009
Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble Humphries, Martin J.; McEwan, Paul A.; Barton, Stephanie J. Trends in Biochemical Sciences, Vol. 28, Issue 6 https://doi.org/10.1016/S0968-0004(03)00112-9	journal	June 2003
Conformational heterogeneity of α -synuclein in membrane Vermaas, Josh V.; Tajkhorshid, Emad Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1838, Issue 12 https://doi.org/10.1016/j.bbamem.2014.08.012	journal	December 2014
Membrane proteins bind lipids selectively to modulate their structure and function Laganowsky, Arthur; Reading, Eamonn; Allison, Timothy M. Nature, Vol. 510, Issue 7503 https://doi.org/10.1038/nature13419	journal	June 2014
Recognition of transmembrane helices by the endoplasmic reticulum translocon Hessa, Tara; Kim, Hyun; Bihlmaier, Karl Nature, Vol. 433, Issue 7024 https://doi.org/10.1038/nature03216	journal	January 2005
Fluorescence Correlation Spectroscopy of Phosphatidylinositol-Specific Phospholipase C Monitors the Interplay of Substrate and Activator Lipid Binding Pu, Mingming; Roberts, Mary F.; Gershenson, Anne Biochemistry, Vol. 48, Issue 29 https://doi.org/10.1021/bi900633p	journal	July 2009
Cytochrome P450 and Chemical Toxicology Guengerich, F. Peter Chemical Research in Toxicology, Vol. 21, Issue 1 https://doi.org/10.1021/tx700079z	journal	January 2008
New PI(4,5)P2- and membrane proximal integrin–binding motifs in the talin head control β3-integrin clustering Saltel, Frédéric; Mortier, Eva; Hytönen, Vesa P. Journal of Cell Biology, Vol. 187, Issue 5 https://doi.org/10.1083/jcb.200908134	journal	November 2009
Dynamical view of membrane binding and complex formation of human factor VIIa and tissue factor Ohkubo, Y. Z.; Morrissey, J. H.; Tajkhorshid, E. Journal of Thrombosis and Haemostasis, Vol. 8, Issue 5 https://doi.org/10.1111/j.1538-7836.2010.03826.x	journal	May 2010
Tissue Factor Positions and Maintains the Factor VIIa Active Site Far above the Membrane Surface Even in the Absence of the Factor VIIa Gla Domain McCallum, Christine D.; Su, Bixia; Neuenschwander, Pierre F. Journal of Biological Chemistry, Vol. 272, Issue 48 https://doi.org/10.1074/jbc.272.48.30160	journal	November 1997
Cooperativity in Cytochrome P450 3A4: LINKAGES IN SUBSTRATE BINDING, SPIN STATE, UNCOUPLING, AND PRODUCT FORMATION Denisov, Ilia G.; Baas, Bradley J.; Grinkova, Yelena V. Journal of Biological Chemistry, Vol. 282, Issue 10 https://doi.org/10.1074/jbc.M609589200	journal	January 2007
Membrane-Bound α-Synuclein Forms an Extended Helix: Long-Distance Pulsed ESR Measurements Using Vesicles, Bicelles, and Rodlike Micelles Georgieva, Elka R.; Ramlall, Trudy F.; Borbat, Peter P. Journal of the American Chemical Society, Vol. 130, Issue 39 https://doi.org/10.1021/ja804517m	journal	October 2008
Membrane proteins: molecular dynamics simulations Lindahl, E.; Sansom, M. Current Opinion in Structural Biology, Vol. 18, Issue 4 https://doi.org/10.1016/j.sbi.2008.02.003	journal	August 2008
Membrane Assembly of Simple Helix Homo-Oligomers Studied via Molecular Dynamics Simulations Bu, Lintao; Im, Wonpil; Brooks, Charles L. Biophysical Journal, Vol. 92, Issue 3 https://doi.org/10.1529/biophysj.106.095216	journal	February 2007
Phospholipid-binding Sites of Phosphatase and Tensin Homolog (PTEN) Wei, Yang; Stec, Boguslaw; Redfield, Alfred G. Journal of Biological Chemistry, Vol. 290, Issue 3 https://doi.org/10.1074/jbc.M114.588590	journal	January 2015
The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor Banner, David W.; D'Arcy, Allan; Chène, Christiana Nature, Vol. 380, Issue 6569 https://doi.org/10.1038/380041a0	journal	March 1996
Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex Ngo, Jacky Chi Ki; Huang, Mingdong; Roth, David A. Structure, Vol. 16, Issue 4 https://doi.org/10.1016/j.str.2008.03.001	journal	April 2008
Arachidonic Acid-metabolizing Cytochrome P450 Enzymes Are Targets of ω-3 Fatty Acids* Arnold, Cosima; Markovic, Marija; Blossey, Katrin Journal of Biological Chemistry, Vol. 285, Issue 43 https://doi.org/10.1074/jbc.M110.118406	journal	October 2010
Interaction of NBD-talin with lipid monolayers: A film balance study Dietrich, C.; Goldmann, W. H.; Sackmann, E. FEBS Letters, Vol. 324, Issue 1 https://doi.org/10.1016/0014-5793(93)81527-7	journal	June 1993
Comparing the polarities of the amino acids: side-chain distribution coefficients between the vapor phase, cyclohexane, 1-octanol, and neutral aqueous solution Radzicka, Anna; Wolfenden, Richard Biochemistry, Vol. 27, Issue 5 https://doi.org/10.1021/bi00405a042	journal	March 1988
From Self-Assembled Vesicles to Protocells Chen, I. A.; Walde, P. Cold Spring Harbor Perspectives in Biology, Vol. 2, Issue 7 https://doi.org/10.1101/cshperspect.a002170	journal	June 2010
The Lipid-binding Domain of Wild Type and Mutant α-Synuclein Georgieva, Elka R.; Ramlall, Trudy F.; Borbat, Peter P. Journal of Biological Chemistry, Vol. 285, Issue 36 https://doi.org/10.1074/jbc.M110.157214	journal	September 2010
Molecular Dynamics Simulations of Large Integral Membrane Proteins with an Implicit Membrane Model Tanizaki, Seiichiro; Feig, Michael The Journal of Physical Chemistry B, Vol. 110, Issue 1 https://doi.org/10.1021/jp054694f	journal	January 2006
The Structure of an Interdomain Complex That Regulates Talin Activity Goult, Benjamin T.; Bate, Neil; Anthis, Nicholas J. Journal of Biological Chemistry, Vol. 284, Issue 22 https://doi.org/10.1074/jbc.M900078200	journal	May 2009
Side-chain hydrophobicity scale derived from transmembrane protein folding into lipid bilayers Moon, C. P.; Fleming, K. G. Proceedings of the National Academy of Sciences, Vol. 108, Issue 25 https://doi.org/10.1073/pnas.1103979108	journal	May 2011
Integrin activation takes shape Liddington, R. C.; Ginsberg, M. H. Journal of Cell Biology, Vol. 158, Issue 5 https://doi.org/10.1083/jcb.200206011	journal	September 2002
A short amino-terminal segment of microsomal cytochrome P-450 functions both as an insertion signal and as a stop-transfer sequence. Sakaguchi, M.; Mihara, K.; Sato, R. The EMBO Journal, Vol. 6, Issue 8 https://doi.org/10.1002/j.1460-2075.1987.tb02521.x	journal	August 1987
From The Cover: Structure of membrane-bound -synuclein studied by site-directed spin labeling Jao, C. C.; Der-Sarkissian, A.; Chen, J. Proceedings of the National Academy of Sciences, Vol. 101, Issue 22 https://doi.org/10.1073/pnas.0400553101	journal	May 2004
Cation−π Interactions As Lipid-Specific Anchors for Phosphatidylinositol-Specific Phospholipase C Grauffel, Cédric; Yang, Boqian; He, Tao Journal of the American Chemical Society, Vol. 135, Issue 15 https://doi.org/10.1021/ja312656v	journal	April 2013
Molecular Basis for Immune Recognition of Exposed Phosphatidylserine via the Tim Family of Proteins Tietjen, Gregory T.; Vargas, Ernesto; Chen, Chiu-Hao Biophysical Journal, Vol. 102, Issue 3 https://doi.org/10.1016/j.bpj.2011.11.2710	journal	January 2012
Biological membranes: the importance of molecular detail Lee, Anthony G. Trends in Biochemical Sciences, Vol. 36, Issue 9 https://doi.org/10.1016/j.tibs.2011.06.007	journal	September 2011
The complete influenza hemagglutinin fusion domain adopts a tight helical hairpin arrangement at the lipid:water interface Lorieau, J. L.; Louis, J. M.; Bax, A. Proceedings of the National Academy of Sciences, Vol. 107, Issue 25 https://doi.org/10.1073/pnas.1006142107	journal	June 2010
Distinct Structural and Adhesive Roles of Ca2+ in Membrane Binding of Blood Coagulation Factors Ohkubo, Y. Zenmei; Tajkhorshid, Emad Structure, Vol. 16, Issue 1 https://doi.org/10.1016/j.str.2007.10.021	journal	January 2008
Mechanosensitive Channel MscS in the Open State: Modeling of the Transition, Explicit Simulations, and Experimental Measurements of Conductance Anishkin, Andriy; Kamaraju, Kishore; Sukharev, Sergei Journal of General Physiology, Vol. 132, Issue 1 https://doi.org/10.1085/jgp.200810000	journal	June 2008
Amyloid Aggregation: Role of Biological Membranes and the Aggregate–Membrane System Bucciantini, Monica; Rigacci, Stefania; Stefani, Massimo The Journal of Physical Chemistry Letters, Vol. 5, Issue 3 https://doi.org/10.1021/jz4024354	journal	January 2014
Molecular Model of Hemoglobin N from Mycobacterium tuberculosis Bound to Lipid Bilayers: A Combined Spectroscopic and Computational Study Rhéault, Jean-François; Gagné, Ève; Guertin, Michel Biochemistry, Vol. 54, Issue 11 https://doi.org/10.1021/bi5010624	journal	March 2015
Insertion of the Ca2+-Independent Phospholipase A2 into a Phospholipid Bilayer via Coarse-Grained and Atomistic Molecular Dynamics Simulations Bucher, Denis; Hsu, Yuan-Hao; Mouchlis, Varnavas D. PLoS Computational Biology, Vol. 9, Issue 7 https://doi.org/10.1371/journal.pcbi.1003156	journal	July 2013
Integrin regulation Ginsberg, Mark H.; Partridge, Anthony; Shattil, Sanford J. Current Opinion in Cell Biology, Vol. 17, Issue 5 https://doi.org/10.1016/j.ceb.2005.08.010	journal	October 2005
Molecular Details of α-Synuclein Membrane Association Revealed by Neutrons and Photons Jiang, Zhiping; Hess, Sara K.; Heinrich, Frank The Journal of Physical Chemistry B, Vol. 119, Issue 14 https://doi.org/10.1021/jp512499r	journal	March 2015
Efficient Exploration of Membrane-Associated Phenomena at Atomic Resolution Vermaas, Josh V.; Baylon, Javier L.; Arcario, Mark J. The Journal of Membrane Biology, Vol. 248, Issue 3 https://doi.org/10.1007/s00232-015-9806-9	journal	May 2015
The MARTINI Force Field: Coarse Grained Model for Biomolecular Simulations Marrink, Siewert J.; Risselada, H. Jelger; Yefimov, Serge The Journal of Physical Chemistry B, Vol. 111, Issue 27 https://doi.org/10.1021/jp071097f	journal	July 2007
α-Synuclein Reduces Tension and Increases Undulations in Simulations of Small Unilamellar Vesicles Braun, Anthony R.; Sachs, Jonathan N. Biophysical Journal, Vol. 108, Issue 8 https://doi.org/10.1016/j.bpj.2015.03.029	journal	April 2015
Molecular dynamics simulations of cholesterol-rich membranes using a coarse-grained force field for cyclic alkanes MacDermaid, Christopher M.; Kashyap, Hemant K.; DeVane, Russell H. The Journal of Chemical Physics, Vol. 143, Issue 24 https://doi.org/10.1063/1.4937153	journal	December 2015
Influenza Virus Entry Luo, Ming Viral Molecular Machines https://doi.org/10.1007/978-1-4614-0980-9_9	book	November 2011
Predictive energy landscapes for folding -helical transmembrane proteins Kim, B. L.; Schafer, N. P.; Wolynes, P. G. Proceedings of the National Academy of Sciences, Vol. 111, Issue 30 https://doi.org/10.1073/pnas.1410529111	journal	July 2014
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature Nelson, David R.; Koymans, Luc; Kamataki, Tetsuya Pharmacogenetics, Vol. 6, Issue 1 https://doi.org/10.1097/00008571-199602000-00002	journal	January 1996
The Structure and Function of the Hemagglutinin Membrane Glycoprotein of Influenza Virus Wiley, D. C.; Skehel, J. J. Annual Review of Biochemistry, Vol. 56, Issue 1 https://doi.org/10.1146/annurev.bi.56.070187.002053	journal	June 1987
Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis Felding-Habermann, B.; Lerner, R. A.; Lillo, A. Proceedings of the National Academy of Sciences, Vol. 101, Issue 49 https://doi.org/10.1073/pnas.0407869101	journal	November 2004
α-Synuclein-Induced Membrane Remodeling Is Driven by Binding Affinity, Partition Depth, and Interleaflet Order Asymmetry Braun, Anthony R.; Lacy, Michael M.; Ducas, Vanessa C. Journal of the American Chemical Society, Vol. 136, Issue 28 https://doi.org/10.1021/ja5016958	journal	July 2014
Talin Binding to Integrin Tails: A Final Common Step in Integrin Activation Tadokoro, S. Science, Vol. 302, Issue 5642 https://doi.org/10.1126/science.1086652	journal	October 2003
A reinterpretation of neutron scattering experiments on a lipidated Ras peptide using replica exchange molecular dynamics Vogel, Alexander; Roark, Matthew; Feller, Scott E. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1818, Issue 2 https://doi.org/10.1016/j.bbamem.2011.08.016	journal	February 2012
Membrane structure and fusion-triggering conformational change of the fusion domain from influenza hemagglutinin Han, Xing; Bushweller, John H.; Cafiso, David S. Nature Structural Biology, Vol. 8, Issue 8, p. 715-720 https://doi.org/10.1038/90434	journal	August 2001
α-Synuclein in Lewy bodies Spillantini, Maria Grazia; Schmidt, Marie Luise; Lee, Virginia M. -Y. Nature, Vol. 388, Issue 6645 https://doi.org/10.1038/42166	journal	August 1997
Site-Specific Interaction between α-Synuclein and Membranes Probed by NMR-Observed Methionine Oxidation Rates Maltsev, Alexander S.; Chen, Jue; Levine, Rodney L. Journal of the American Chemical Society, Vol. 135, Issue 8 https://doi.org/10.1021/ja312415q	journal	February 2013
Membrane Docking Geometry and Target Lipid Stoichiometry of Membrane-Bound PKCα C2 Domain: A Combined Molecular Dynamics and Experimental Study Lai, Chun-Liang; Landgraf, Kyle E.; Voth, Gregory A. Journal of Molecular Biology, Vol. 402, Issue 2 https://doi.org/10.1016/j.jmb.2010.07.037	journal	September 2010
Molecular Mechanism of Membrane Binding of the GRP1 PH Domain Lai, Chun-Liang; Srivastava, Anand; Pilling, Carissa Journal of Molecular Biology, Vol. 425, Issue 17 https://doi.org/10.1016/j.jmb.2013.05.026	journal	September 2013
PSII–LHCII Supercomplex Organizations in Photosynthetic Membrane by Coarse-Grained Simulation Lee, Cheng-Kuang; Pao, Chun-Wei; Smit, Berend The Journal of Physical Chemistry B, Vol. 119, Issue 10 https://doi.org/10.1021/jp511277c	journal	February 2015
Inter-Helix Distances in Lysophospholipid Micelle-Bound α-Synuclein from Pulsed ESR Measurements Borbat, Peter; Ramlall, Trudy F.; Freed, Jack H. Journal of the American Chemical Society, Vol. 128, Issue 31 https://doi.org/10.1021/ja063122l	journal	August 2006

Similar Records

Deuterium nuclear magnetic resonance study of protein dynamics and protein-lipid interactions in model and biological membranes

Thesis/Dissertation · Sun Jan 01 00:00:00 EST 1984 · OSTI ID:1367694

Kintanar, A B

Penetration of the signal sequence of Escherichia coli PhoE protein into phospholipid model membranes leads to lipid-specific changes in signal peptide structure and alterations of lipid organization

Journal Article · Tue Jul 26 00:00:00 EDT 1988 · Biochemistry; (United States) · OSTI ID:1367694

Batenburg, A M; Demel, R A; Verkleij, A J; +1 more

Effect of hydrodynamic interactions on the tracer and gradient diffusion of integral membrane proteins in lipid bilayers

Journal Article · Sat Jan 01 00:00:00 EST 1994 · Journal of Fluid Mechanics · OSTI ID:1367694

Bussell, S J; Hammer, D A; Koch, D L

Title: Atomic-level description of protein–lipid interactions using an accelerated membrane model

Citation Formats

References (177)

Similar Records

Related Subjects