Separation of 44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44Ti/44Sc generator system

Radchenko, Valery; Meyer, Catherine Anne Louise; Engle, Jonathan Ward; Naranjo, Cleo Micah; Unc, George A.; Mastren, Tara; Brugh, Mark; Birnbaum, Eva R.; John, Kevin Dale; Nortier, Francois Meiring; Fassbender, Michael Ernst

doi:10.1016/j.chroma.2016.11.047

Title: Separation of ⁴⁴Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of ⁴⁴Ti/⁴⁴Sc generator system

Journal Article · Thu Nov 24 00:00:00 EST 2016 · Journal of Chromatography

DOI:https://doi.org/10.1016/j.chroma.2016.11.047· OSTI ID:1364573

Radchenko, Valery ^[1]; Meyer, Catherine Anne Louise ^[1]; Engle, Jonathan Ward ^[1]; Naranjo, Cleo Micah ^[1]; Unc, George A. ^[1];

^[1]; Brugh, Mark ^[1];

^[1];

^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Scandium-44 g (half-life 3.97 h) shows promise for positron emission tomography (PET) imaging of longer biological processes than that of the current gold standard, ¹⁸F, due to its favorable decay parameters. One source of ⁴⁴gSc is the long-lived parent nuclide ⁴⁴Ti (half-life 60.0 a). A ⁴⁴Ti/⁴⁴gSc generator would have the ability to provide radionuclidically pure ⁴⁴gSc on a daily basis. The production of ⁴⁴Ti via the ⁴⁵Sc(p,2n) reaction requires high proton beam currents and long irradiation times. Recovery and purification of no-carrier added (nca) ⁴⁴Ti from scandium metal targets involves complex separation chemistry. In this study, separation systems based on solid phase extraction chromatography were investigated, including branched diglycolamide (BDGA) resin and hydroxamate based ZR resin. Lastly, results indicate that ZR resin in HCl media represents an effective ⁴⁴Ti/⁴⁴gSc separation system.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP)

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1364573

Alternate ID(s):: OSTI ID: 1413378

Report Number(s):: LA-UR-16-25223

Journal Information:: Journal of Chromatography, Vol. 1477, Issue A; ISSN 0021-9673

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 30 works

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Separation and purification of scandium: From industry to medicine Pyrzyńska, Krystyna; Kilian, Krzysztof; Pęgier, Mateusz Separation & Purification Reviews, Vol. 48, Issue 1 https://doi.org/10.1080/15422119.2018.1430589	journal	January 2018
New developments in the production of theranostic pairs of radionuclides Qaim, Syed M.; Scholten, Bernhard; Neumaier, Bernd Journal of Radioanalytical and Nuclear Chemistry, Vol. 318, Issue 3 https://doi.org/10.1007/s10967-018-6238-x	journal	October 2018

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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scandium metal target
solid phase extraction chromatography
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Title: Separation of 44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44Ti/44Sc generator system

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