When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins

Leung, Daisy W.; Amarasinghe, Gaya K.

doi:10.1016/j.sbi.2016.02.001

Title: When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins

Journal Article · Tue Feb 23 00:00:00 EST 2016 · Current Opinion in Structural Biology

DOI:https://doi.org/10.1016/j.sbi.2016.02.001· OSTI ID:1351403

Leung, Daisy W. ^[1]; Amarasinghe, Gaya K. ^[1]

Washington Univ., St. Louis, MO (United States)

Cytosolic recognition of viral RNA is important for host innate immune responses. Differential recognition of self vs non-self RNA is a considerable challenge as the inability to differentiate may trigger aberrant immune responses. Recent work identified the composition of the RNA 5', including the 5' cap and its methylation state, as an important determinant of recognition by the host. Furthermore, recent studies have advanced our understanding of the modified 5' RNA recognition and viral antagonism of RNA receptors. Here, we will discuss RIG-I and IFIT proteins as examples of host proteins that detect dsRNA and ssRNA, respectively.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH); USDOD Defense Threat Reduction Agency (DTRA)

Grant/Contract Number:: R01AI107056; R01AI123926; R01AI114654; U191099565; U19AI109945; U19AI109664; HDTRA1-14-0013; HDTRA1-12-1-0051

OSTI ID:: 1351403

Journal Information:: Current Opinion in Structural Biology, Vol. 36, Issue C; ISSN 0959-440X

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 38 works

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59 BASIC BIOLOGICAL SCIENCES
RNA cap
RIG-I
MDA-5
IFIT
IFN

Title: When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins

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