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Title: Novel mass spectrometry mutation screening for contaminant impact analysis. 1998 annual progress report

'The objective is to develop innovative mass spectrometry technology to achieve fast mutation screening from contaminated area and to reveal the linkage between gene mutation and contaminants. In this program, the author will try innovative approaches to improve mass resolution and detection efficiency for large DNA ions. Allel specific polymerase chain reaction will be coupled with mass spectrometry for rapid DNA mutation detection. The ultimate goal is to lead to the risk analysis of hazardous wastes to be routinely assessed at DNA level at an affordable cost. This report is for the work after 7 months of a 3-year project.'
Authors:
Publication Date:
OSTI Identifier:
13461
Report Number(s):
EMSP-60218--98
ON: DE00013461
Resource Type:
Technical Report
Research Org:
Oak Ridge National Lab., TN (US)
Sponsoring Org:
USDOE Office of Environmental Management (EM), Office of Science and Risk Policy
Country of Publication:
United States
Language:
English
Subject:
44; 55; 54; Progress Report; Progress Report; Measuring Instruments; Measuring Instruments; Medicine; Medicine; Microorganisms; Microorganisms; Genetics; Genetics; Health Hazards; Health Hazards; Ecology; Ecology; Risk Assessment; Risk Assessment; Remedial Action; Remedial Action PROGRESS REPORT; MEASURING INSTRUMENTS; MEDICINE; MICROORGANISMS; GENETICS; HEALTH HAZARDS; ECOLOGY; RISK ASSESSMENT; REMEDIAL ACTION