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Title: Interactions of 1D- and 2D-layered inorganic nanoparticles with fibroblasts and human mesenchymal stem cells

Here, this study investigates the effects of tungsten disulfide nanotubes (WSNTs) and molybdenum disulfide nanoplatelets (MSNPs) on fibroblasts (NIH-3T3) and mesenchymal stem cells (MSCs) to determine safe dosages for potential biomedical applications. Cytotoxicity of MSNPs and WSNTs (5–300 μg/ml) on NIH-3T3 and MSCs was assessed at 6, 12 or 24 h. MSC differentiation to adipocytes and osteoblasts was assessed following treatment for 24 h. Only NIH-3T3 cells treated with MSNPs showed dose or time dependent increase in cytotoxicity. Differentiation markers of MSCs in treated groups were unaffected compared with untreated controls. In conclusion, MSNPs and WSNTs at concentrations less than 50 μg/ml are potentially safe for treatment of fibroblasts or MSCs for up to 24 h.
Authors:
 [1] ;  [1] ;  [1] ;  [1]
  1. Stony Brook Univ., Stony Brook, NY (United States). Dept. of Biomedical Engineering
Publication Date:
OSTI Identifier:
1345589
Grant/Contract Number:
AC02-98CH10886; 1DP2OD007394-01
Type:
Accepted Manuscript
Journal Name:
Nanomedicine
Additional Journal Information:
Journal Volume: 10; Journal Issue: 11; Journal ID: ISSN 1743-5889
Publisher:
Future Medicine
Research Org:
Stony Brook Univ., Stony Brook, NY (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 59 BASIC BIOLOGICAL SCIENCES; cytotoxicity; differentiation; inorganic nanoparticles; stem cells; tissue engineering; uptake