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Title: Insights into the structure and function of membrane-integrated processive glycosyltransferases

Complex carbohydrates perform essential functions in life, including energy storage, cell signaling, protein targeting, quality control, as well as supporting cell structure and stability. Extracellular polysaccharides (EPS) represent mainly structural polymers and are found in essentially all kingdoms of life. For example, EPS are important biofilm and capsule components in bacteria, represent major constituents in cell walls of fungi, algae, arthropods and plants, and modulate the extracellular matrix in vertebrates. Different mechanisms evolved by which EPS are synthesized. In this paper, we review the structures and functions of membrane-integrated processive glycosyltransferases (GTs) implicated in the synthesis and secretion of chitin, alginate, hyaluronan and poly-N-acetylglucosamine (PNAG).
Authors:
ORCiD logo [1] ;  [1] ;  [1] ;  [1]
  1. Univ. of Virginia, Charlottesville, VA (United States)
Publication Date:
OSTI Identifier:
1344504
Grant/Contract Number:
SC0001090
Type:
Accepted Manuscript
Journal Name:
Current Opinion in Structural Biology
Additional Journal Information:
Journal Volume: 34; Journal ID: ISSN 0959-440X
Publisher:
Elsevier
Research Org:
Univ. of Virginia, Charlottesville, VA (United States)
Sponsoring Org:
USDOE Office of Science (SC)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES