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Title: Bacterial production of methyl ketones

Abstract

The present invention relates to methods and compositions for increasing production of methyl ketones in a genetically modified host cell that overproduces .beta.-ketoacyl-CoAs through a re-engineered .beta.-oxidation pathway and overexpresses FadM.

Inventors:
;
Publication Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1342098
Patent Number(s):
9,556,458
Application Number:
14/354,510
Assignee:
The Regents of the University of California
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Oct 26
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Beller, Harry R., and Goh, Ee-Been. Bacterial production of methyl ketones. United States: N. p., 2017. Web.
Beller, Harry R., & Goh, Ee-Been. Bacterial production of methyl ketones. United States.
Beller, Harry R., and Goh, Ee-Been. 2017. "Bacterial production of methyl ketones". United States. https://www.osti.gov/servlets/purl/1342098.
@article{osti_1342098,
title = {Bacterial production of methyl ketones},
author = {Beller, Harry R. and Goh, Ee-Been},
abstractNote = {The present invention relates to methods and compositions for increasing production of methyl ketones in a genetically modified host cell that overproduces .beta.-ketoacyl-CoAs through a re-engineered .beta.-oxidation pathway and overexpresses FadM.},
doi = {},
url = {https://www.osti.gov/biblio/1342098}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 31 00:00:00 EST 2017},
month = {Tue Jan 31 00:00:00 EST 2017}
}

Works referenced in this record:

Production of fatty acid esters
patent-application, October 2010


Fatty Acid-Producing Hosts
patent, July 2011


Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals
journal, August 2011


Identification of β-oxidation and thioesterase activities inStaphylococcus carnosus833 strain
journal, September 2000


Substantial improvements in methyl ketone production in E. coli and insights on the pathway from in vitro studies
journal, November 2014


Synthesis of methyl ketones by metabolically engineered Escherichia coli
journal, August 2012