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Title: Role of CTGF in sensitivity to hyperthermia in ovarian and uterine cancers

Journal Article · · Cell Reports
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  1. The Univ. of Texas MD Anderson Cancer Center (MDACC), Houston, TX (United States); Chiba Univ., Chiba (Japan)
  2. The Univ. of Texas MD Anderson Cancer Center (MDACC), Houston, TX (United States)
  3. MDACC, Houston, TX (United States)
  4. Univ. of Puerto Rico-Mayaguez, Mayaguez (Puerto Rico)
  5. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  6. The Univ. of Texas MD Anderson Cancer Center (MDACC), Houston, TX (United States); Hokkaido Univ. Graduate School of Medicine, Sapporo (Japan)
  7. Catholic Univ. of the Sacred Heart, Rome (Italy)
+ Show Author Affiliations

Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. Lastly, CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
AC05-76RL01830
OSTI ID:
1339834
Report Number(s):
PNNL-SA-120868; 48666; 453040220
Journal Information:
Cell Reports, Vol. 17, Issue 6; ISSN 2211-1247
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 16 works
Citation information provided by
Web of Science

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Cited By (6)

Development and Assessment of Nano-Technologies for Cancer Treatment: Cytotoxicity and Hyperthermia Laboratory Studies journal December 2019
Down‐regulation of interferon regulatory factor 2 binding protein 2 suppresses gastric cancer progression by negatively regulating connective tissue growth factor journal September 2019
Overexpression of connective tissue growth factor is associated with tumor progression and unfavorable prognosis in endometrial cancer journal August 2019
Development and Assessment of Nano-Technologies for Cancer Treatment: Cytotoxicity and Hyperthermia Laboratory Studies text January 2020
Development and Assessment of Nano-Technologies for Cancer Treatment: Cytotoxicity and Hyperthermia Laboratory Studies text January 2020
Connective tissue growth factor mediates TGF-β1-induced low-grade serous ovarian tumor cell apoptosis journal July 2017

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Related Subjects

60 APPLIED LIFE SCIENCES
Environmental Molecular Sciences Laboratory
hyperthermia
ovarian cancer
CTGF
DOPC-liposome
thermosensitivity
copper sulfide nanoparticle