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Title: The landscape of viral proteomics and its potential to impact human health

Translating the intimate discourse between viruses and their host cells during infection is a challenging but critical task for development of antiviral interventions and diagnostics. Viruses commandeer cellular processes at every step of their life cycle, altering expression of genes and proteins. Advances in mass spectrometry-based proteomic technologies are enhancing studies of viral pathogenesis by identifying virus-induced changes in the protein repertoire of infected cells or extracellular fluids. Interpretation of proteomics results using knowledge of cellular pathways and networks leads to identification of proteins that influence a range of infection processes, thereby focusing efforts for clinical diagnoses and therapeutics development. Herein we discuss applications of global proteomic studies of viral infections with the goal of providing a basis for improved studies that will benefit community-wide data integration and interpretation.
Authors:
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Publication Date:
OSTI Identifier:
1324905
Report Number(s):
PNNL-SA-116259
Journal ID: ISSN 1478-9450; 400904120
DOE Contract Number:
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Expert Review of Proteomics; Journal Volume: 13; Journal Issue: 6
Publisher:
Taylor & Francis
Research Org:
Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
biomarkers; host-virus interactions; mass spectrometry; pathway analysis; PTM; serum proteomics