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Title: Recoding method that removes inhibitory sequences and improves HIV gene expression

The invention relates to inhibitory nucleotide signal sequences or "INS" sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes.
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
1303730
Report Number(s):
9,422,342
12/373,605
DOE Contract Number:
FG02-90ER40542
Resource Type:
Patent
Resource Relation:
Patent File Date: 2007 Jul 12
Research Org:
Institute of Advanced Study, Princeton, NJ (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES