Self-Assembling Biological Springs Force Transducers on the Micron Nanoscale
In this project, we are developing a new system for measuring forces within and between nanoscale biological molecules based on mesoscopic springs made of cholesterol helical ribbons. These ribbons self-assemble in a wide variety of complex fluids containing sterol, a mixture of surfactants and water  and have spring constants in the range from 0.5 to 500 pN/nm [2-4]. By the end of this project, we have demonstrated that the cholesterol helical ribbons can be used for measuring forces between biological objects and for mapping the strain fields in hydrogels.
- Publication Date:
- OSTI Identifier:
- DOE Contract Number:
- Resource Type:
- Technical Report
- Research Org:
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
- Sponsoring Org:
- USDOE Chicago Operations Office (CO)
- Country of Publication:
- United States
- 59 BASIC BIOLOGICAL SCIENCES
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