Direct Aqueous-Phase Synthesis of Sub-10 nm “Luminous Pearls” with Enhanced in Vivo Renewable Near-Infrared Persistent Luminescence

Li, Zhanjun; Zhang, Yuanwei; Wu, Xiang; Huang, Ling; Li, Dongsheng; Fan, Wei; Han, Gang

doi:10.1021/jacs.5b00872

Title: Direct Aqueous-Phase Synthesis of Sub-10 nm “Luminous Pearls” with Enhanced in Vivo Renewable Near-Infrared Persistent Luminescence

Journal Article · Thu Apr 02 00:00:00 EDT 2015 · Journal of the American Chemical Society

DOI:https://doi.org/10.1021/jacs.5b00872· OSTI ID:1295296

Li, Zhanjun ^[1]; Zhang, Yuanwei ^[1]; Wu, Xiang ^[1]; Huang, Ling ^[1]; Li, Dongsheng ^[2]; Fan, Wei ^[3]; Han, Gang ^[1]

Univ. of Massachusetts Medical School, Worcester, MA (United States). Dept. of Biochemistry and Molecular Pharmacology
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Materials Sciences, Physical Sciences Division
Univ. of Massachusetts, Amherst, MA (United States). Dept. of Chemical Engineering

Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs), possessing unique NIR PL properties, have recently emerged as important materials for a wide variety of applications in chemistry and biology, for which they must endure high-temperature solid-state annealing reactions and subsequent complicated physical post-treatments. Herein, we report on a first direct aqueous-phase chemical synthesis route to NIR PLNPs and present their enhanced in vivo renewable NIR PL. Our method leads to monodisperse PLNPs as small as ca. 8 nm. Such sub-10 nm nanocrystals are readily dispersed and functionalized, and can form stable colloidal solutions in aqueous solution and cell culture medium for biological applications. Under biotissue-penetrable red-light excitation, we found that such nanocrystals possess superior renewable PL photoluminescence in vitro and in vivo compared to their larger counterparts currently made by existing methods. In conclusion, we believe that this solid-state-reaction-free chemical approach overcomes the current key roadblock in regard to PLNP development, and thus will pave the way to broad use of these advanced miniature “luminous pearls” in photonics and biophotonics.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE

Grant/Contract Number:: AC05-76RL01830; R01MH103133; RGY0090/2014

OSTI ID:: 1295296

Journal Information:: Journal of the American Chemical Society, Vol. 137, Issue 16; ISSN 0002-7863

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 320 works

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