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Title: A Structures for Lossless Ion Manipulations (SLIM) Module for Collision Induced Dissociation

A collision induced dissociation (CID) structures for lossless ion manipulations (SLIM) module is introduced and coupled to a quadrupole time-of-flight (QTOF) mass spectrometer (MS). The SLIM CID module was mounted after an ion mobility (IM) drift tube to enable IM/CID/MS studies. The efficiency of CID was studied by using the model peptide leucine enkephalin. CID efficiencies (62%) compared favorably to other beam-type CID methods. Additionally, the SLIM CID module was used to fragment a mixture of 9 peptides after IM separation. This work also represents the first application of SLIM in the 0.3 to 0.5 Torr pressure regime, an order of magnitude lower in pressure than previously studied.
Authors:
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Publication Date:
OSTI Identifier:
1290401
Report Number(s):
PNNL-SA-115654
Journal ID: ISSN 1044-0305; 48680; 48135; KP1601010
DOE Contract Number:
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of the American Society for Mass Spectrometry; Journal Volume: 27; Journal Issue: 7
Publisher:
American Society for Mass Spectrometry
Research Org:
Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
Collision Induced Dissociation; Ion mobility spectrometry; RF Confinement; ion optics; peptide fragmentation; manipulation; conveyor; Environmental Molecular Sciences Laboratory