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Title: Steering microtubule shuttle transport with dynamically controlled magnetic fields

Journal Article · · Nanoscale
DOI:https://doi.org/10.1039/c5nr08529b· OSTI ID:1285955
 [1];  [2];  [1];  [3];  [1];  [4];  [1];  [4];  [3];  [5]
  1. The Ohio State Univ., Columbus, OH (United States). William G. Lowrie Dept. of Chemical and Biomolecular Engineering
  2. The Ohio State Univ., Columbus, OH (United States). William G. Lowrie Dept. of Chemical and Biomolecular Engineering; Nanjing Univ. (China). College of Engineering and Applied Sciences, Dept. of Biomedical Engineering
  3. The Ohio State Univ., Columbus, OH (United States). Dept of Physics
  4. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Center for Integrated Nanotechnologies
  5. The Ohio State Univ., Columbus, OH (United States). William G. Lowrie Dept. of Chemical and Biomolecular Engineering; The Ohio State Univ., Columbus, OH (United States). Dept of Biomedical Engineering
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Nanoscale control of matter is critical to the design of integrated nanosystems. Here, we describe a method to dynamically control directionality of microtubule (MT) motion using programmable magnetic fields. MTs are combined with magnetic quantum dots (i.e., MagDots) that are manipulated by external magnetic fields provided by magnetic nanowires. MT shuttles thus undergo both ATP-driven and externally-directed motion with a fluorescence component that permits simultaneous visualization of shuttle motion. This technology is used to alter the trajectory of MTs in motion and to pin MT motion. Ultimately, such an approach could be used to evaluate the MT-kinesin transport system and could serve as the basis for improved lab-on-a-chip technologies based on MT transport.

Research Organization:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES); USDOE National Nuclear Security Administration (NNSA)
Grant/Contract Number:
AC04-94AL85000; CMMI-0900377; DMR-1206745; EEC-0914790; DMR-0820414; W911NF-14-1-0289
OSTI ID:
1285955
Report Number(s):
SAND2016-7202J; NANOHL; 646152
Journal Information:
Nanoscale, Vol. 8, Issue 16; ISSN 2040-3364
Publisher:
Royal Society of ChemistryCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 9 works
Citation information provided by
Web of Science

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Azobenzene‐Based Photoswitches Facilitating Reversible Regulation of Kinesin and Myosin Motor Systems for Nanotechnological Applications journal April 2019

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