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Title: Disposition of the Dietary Mutagen 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Healthy and Pancreatic Cancer Compromised Humans

Journal Article · · Chemical Research in Toxicology
 [1];  [1];  [1];  [2];  [3];  [3];  [3]
  1. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Biosciences and Biotechnology Division
  2. Univ. of Alabama, Birmngham, AL (United States)
  3. Univ. of Minnesota, Minneapolis, MN (United States)
+ Show Author Affiliations

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE; National Inst. of General Medical Sciences
Grant/Contract Number:
AC52-07NA27344; P50 CA101955-07; 2P41GM103483-16
OSTI ID:
1282119
Alternate ID(s):
OSTI ID: 1367983
Report Number(s):
LLNL-JRNL-679828
Journal Information:
Chemical Research in Toxicology, Vol. 29, Issue 3; ISSN 0893-228X
Publisher:
American Chemical Society (ACS)Copyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 8 works
Citation information provided by
Web of Science

References (34)

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Meat and fish consumption and risk of pancreatic cancer: Results from the European Prospective Investigation into Cancer and Nutrition journal June 2012
Meat intake and cooking techniques: associations with pancreatic cancer journal September 2002
Dietary Intake of Heterocyclic Amines and Benzo(a)Pyrene: Associations with Pancreatic Cancer journal September 2005
Dietary Mutagen Exposure and Risk of Pancreatic Cancer journal April 2007
Meat and Meat-Mutagen Intake and Pancreatic Cancer Risk in the NIH-AARP Cohort journal December 2007
A Prospective Study of Meat and Meat Mutagens and Prostate Cancer Risk journal December 2005
Well-Done Meat Intake, Heterocyclic Amine Exposure, and Cancer Risk journal July 2009
Pancreatic cancer risk: Associations with meat-derived carcinogen intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort journal December 2011
Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5- f ]quinoxaline journal January 1988
Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) from cooked foods journal January 1987
Meat-Related Mutagens and Pancreatic Cancer: Null Results from a Clinic-Based Case–Control Study journal April 2013
Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA. journal July 1990
Accelerator Mass Spectrometry journal June 1995
Metabolism of the Food-Borne Mutagen 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Humans journal March 1998
Tissue distribution and macromolecular binding of extremely low doses of [14C]-benzene in B6C3F1 mice journal December 1997
A High-Throughput Method for the Conversion of CO 2 Obtained from Biochemical Samples to Graphite in Septa-Sealed Vials for Quantification of 14 C via Accelerator Mass Spectrometry journal May 2003
Rapid Production of Graphite Without Contamination for Biomedical AMS journal January 1992
Metabolism of 2-Amino-3,8-dimethylimidazo[4,5- f ]- quinoxaline in Human Hepatocytes:  2-Amino-3-methylimidazo[4,5- f ]quinoxaline-8-carboxylic Acid Is a Major Detoxication Pathway Catalyzed by Cytochrome P450 1A2 journal January 2001
Red Meat-Derived Heterocyclic Amines Increase Risk of Colon Cancer: A Population-Based Case-Control Study journal November 2013
Heterocyclic Amines, Meat Intake, and Association with Colon Cancer in a Population-based Study journal March 2003
Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk journal September 2002
Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer journal May 2012
A study of malabsorption in pancreatic cancer journal January 1996
DNA Adducts Formed by 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Rat Liver: Dose-Response on Chronic Administration journal May 1990
Comparison of DNA‐adduct and tissue‐available dose levels of MeIQx in human and rodent colon following administration of a very low dose journal February 1999
DNA Modification by 2-Amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine in Rats journal December 1989
Effect of N -Acetyltransferase 2 Polymorphism on Tumor Target Tissue DNA Adduct Levels in Rapid and Slow Acetylator Congenic Rats Administered 2-Amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine or 2-Amino-3,8-dimethylimidazo-[4,5- f ]quinoxaline journal August 2009
Cytochrome P450-Mediated Metabolism and DNA Binding of 2-Amino-1,7-dimethylimidazo[4,5- g ]quinoxaline and Its Carcinogenic Isomer 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Mice journal December 2011
Pancreatic DNA adducts formed in vitro and in vivo by the food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC) journal August 1997
Detection of 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP)–DNA adducts in human pancreatic tissues journal January 2006
MeIQx-DNA adduct formation in rodent and human tissues at low doses journal May 1997
Red Meat Intake, Doneness, Polymorphisms in Genes that Encode Carcinogen-Metabolizing Enzymes, and Colorectal Cancer Risk journal November 2008

Cited By (1)

Environmental risk factors for pancreatic cancer: an update journal August 2016

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