Commentary on Inhaled 239PuO2 in Dogs — A Prophylaxis against Lung Cancer?
Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The observations conform to the expectations of the radiation hormesis dose-response model and contradict the predictions of the LNT hypothesis. These studies suggest investigating the possibility of employing low-dose alpha-radiation, such as from 239PuO2 inhalation, as a prophylaxis against lung cancer.
- Cuttler & Associates, Vaughan, ON (Canada)
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- Publication Date:
- OSTI Identifier:
- Accepted Manuscript
- Journal Name:
- Additional Journal Information:
- Journal Volume: 13; Journal Issue: -1; Journal ID: ISSN 1559-3258
- International Hormesis Society
- Research Org:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Org:
- Country of Publication:
- United States
- 60 APPLIED LIFE SCIENCES; plutonium-dioxide; inhalation; lung cancer; prophylaxis; radiation hormesis; adaptive protection
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