Restricted mobility of specific functional groups reduces anti-cancer drug activity in healthy cells

Martins, Murillo L.; Ignazzi, Rosanna; Eckert, Juergen; Watts, Benjamin; Kaneno, Ramon; Zambuzzi, Willian F.; Daemen, Luke; Saeki, Margarida J.; Bordallo, Heloisa N.

doi:10.1038/srep22478

Title: Restricted mobility of specific functional groups reduces anti-cancer drug activity in healthy cells

Journal Article · Wed Mar 02 00:00:00 EST 2016 · Scientific Reports

DOI:https://doi.org/10.1038/srep22478· OSTI ID:1259309

Martins, Murillo L. ^[1]; Ignazzi, Rosanna ^[2]; Eckert, Juergen ^[3]; Watts, Benjamin ^[4]; Kaneno, Ramon ^[5]; Zambuzzi, Willian F. ^[5]; Daemen, Luke ^[6]; Saeki, Margarida J. ^[5]; Bordallo, Heloisa N. ^[7]

Univ. of Copenhagen, Copenhagen (Denmark); Univ. Estadual Paulista (Brazil)
Univ. of Copenhagen, Copenhagen (Denmark)
Univ. of South Florida, Tampa, FL (United States); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Paul Scherrer Inst. (PSI), Villigen (Switzerland)
Univ. Estadual Paulista (Brazil)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Univ. of Copenhagen, Copenhagen (Denmark); European Spallation Source ESS AB, Lund (Sweden)

We report that the most common cancer treatments currently available are radio- and chemo-therapy. These therapies have, however, drawbacks, such as, the reduction in quality of life and the low efficiency of radiotherapy in cases of multiple metastases. To lessen these effects, we have encapsulated an anti-cancer drug into a biocompatible matrix. In-vitro assays indicate that this bio-nanocomposite is able to interact and cause morphological changes in cancer cells. Meanwhile, no alterations were observed in monocytes and fibroblasts, indicating that this system might carry the drug in living organisms with reduced clearance rate and toxicity. X-rays and neutrons were used to investigate the carrier structure, as well as to assess the drug mobility within the bio-nanocomposite. In conclusion, from these unique data we show that partial mobility restriction of active groups of the drug molecule suggests why this carrier design is potentially safer to healthy cells.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC52-06NA25396; 05KS4WE1/6; 05KS7WE1

OSTI ID:: 1259309

Alternate ID(s):: OSTI ID: 1259967

Report Number(s):: LA-UR-15-25561; srep22478

Journal Information:: Scientific Reports, Vol. 6; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 7 works

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