skip to main content

This content will become publicly available on June 16, 2016

Title: Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse

Understanding x-ray radiation damage is a crucial issue for both medical applications of x rays and x-ray free-electron-laser (XFEL) science aimed at molecular imaging. Decrypting the charge and fragmentation dynamics of nucleobases, the smallest units of a macro-biomolecule, contributes to a bottom-up understanding of the damage via cascades of phenomena following x-ray exposure. We investigate experimentally and by numerical simulations the ultrafast radiation damage induced on a nucleobase analogue (5-iodouracil) by an ultrashort (10 fs) high-intensity radiation pulse generated by XFEL at SPring-8 Angstrom Compact free electron Laser (SACLA). The present study elucidates a plausible underlying radiosensitizing mechanism of 5-iodouracil. This mechanism is independent of the exact composition of 5-iodouracil and thus relevant to other such radiosensitizers. Furthermore, we found that despite a rapid increase of the net molecular charge in the presence of iodine, and of the ultrafast release of hydrogen, the other atoms are almost frozen within the 10-fs duration of the exposure. Finally, this validates single-shot molecular imaging as a consistent approach, provided the radiation pulse used is brief enough.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [5] ;  [2] ;  [2] ;  [2] ;  [6] ;  [6] ;  [7] ;  [8] ;  [9] ;  [9] ;  [10] ;  [11] ;  [12] ;  [13] ;  [14] ;  [15] more »;  [13] ;  [15] ;  [16] ;  [17] ;  [9] ;  [18] ;  [19] ;  [4] « less
  1. Kyoto Univ., Kyoto (Japan). Dept. of Physics, Graduate School of Science; RIKEN Spring-8 Center, Sayo (Japan)
  2. Tohoku Univ., Sendai (Japan). Inst. of Multidisciplinary Research for Advanced Materials
  3. Univ. of Turku, Turku (Finland). Dept. of Physics and Astronomy
  4. RIKEN Spring-8 Center, Sayo (Japan); Tohoku Univ., Sendai (Japan). Inst. of Multidisciplinary Research for Advanced Materials
  5. RIKEN Spring-8 Center, Sayo (Japan); Hiroshima Univ., Higashi-Hiroshima (Japan). Dept. of Physical Science
  6. Kyoto Univ., Kyoto (Japan). Dept. of Physics. Graduate School of Science
  7. Hiroshima Univ., Higashi-Hiroshima (Japan). Dept. of Physical Science
  8. Kyoto Univ., Kyoto (Japan). Dept. of Physics. Graduate School of Science; Hiroshima Inst. of Technology, Hiroshima (Japan). Research Center for Condensed Matter Physics
  9. Tohoku Univ., Sendai (Japan). Dept. of Chemistry. Graduate School of Science
  10. Kansas State Univ., Manhattan, KS (United States). J.R. Macdonald Lab. Dept. of Physics
  11. Synchrotron SOLEIL, Saint-Aubin (France)
  12. Synchrotron SOLEIL, Saint-Aubin (France); Beihang Univ., Beijing (China). School of Physics and Nuclear Energy Engineering
  13. Chinese Academy of Sciences, Shanghai (China). Shanghai Advanced Research Inst.
  14. Chinese Academy of Sciences, Shanghai (China). Shanghai Inst. of Applied Physics
  15. Pohang Univ. of Science and Technology, Pohang (South Korea). Dept. of Physics. Center for Attosecond Science and Technology; Max Planck Center for Attosecond Science, Pohang (South Korea). Max Planck POSTECH/KOREA Research Initiative
  16. Japan Synchrotron Radiation Research Inst. (JASRI), Sayo, Hyogo (Japan).
  17. RIKEN Spring-8 Center, Sayo (Japan); Japan Synchrotron Radiation Research Inst. (JASRI), Sayo, Hyogo (Japan).
  18. Synchrotron SOLEIL, Saint-Aubin (France); Horia Hulubei National Inst. for Physics and Nuclear Engineering, Magurele (Romania). Extreme Light Infrastructure Nuclear Physics (ELI-NP)
  19. Kyoto Univ., Kyoto (Japan). Dept. of Physics, Graduate School of Science
Publication Date:
OSTI Identifier:
1257647
Grant/Contract Number:
FG02-86ER13491; FG02-86ER1349
Type:
Published Article
Journal Name:
Physical Review. X
Additional Journal Information:
Journal Volume: 6; Journal Issue: 2; Journal ID: ISSN 2160-3308
Publisher:
American Physical Society
Research Org:
Kansas State University
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
Language:
English
Subject:
73 NUCLEAR PHYSICS AND RADIATION PHYSICS; ionization; charge; molecules; operation; region; atoms