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Title: Structures of EccB 1 and EccD 1 from the core complex of the mycobacterial ESX-1 type VII secretion system

Journal Article · · BMC Structural Biology (Online)

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
UNIVERSITYNIHNIAIDDOE - BIOLOGICAL AND ENVIRONMENTAL RESEARCHOTHERHHMINIGMS
OSTI ID:
1255298
Journal Information:
BMC Structural Biology (Online), Vol. 16, Issue (5) ; 2016; ISSN 1472-6807
Publisher:
BioMed Central
Country of Publication:
United States
Language:
ENGLISH

References (62)

Linking Crystallographic Model and Data Quality journal May 2012
Electrostatics of nanosystems: Application to microtubules and the ribosome journal August 2001
Very fast empirical prediction and rationalization of protein pKa values journal October 2005
ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria journal September 2009
Pour some sugar on it: the expanding world of bacterial protein O -linked glycosylation : Protein journal June 2013
Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis: RD1 genes affect secretion and virulence of M. tuberculosis journal January 2004
Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria journal May 2015
Linked Domain Architectures Allow for Specialization of Function in the FtsK/SpoIIIE ATPases of ESX Secretion Systems journal March 2015
Heterologous Expression of Mycobacterial Esx Complexes in Escherichia coli for Structural Studies Is Facilitated by the Use of Maltose Binding Protein Fusions journal November 2013
Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition journal October 2009
The Phyre2 web portal for protein modeling, prediction and analysis journal May 2015
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti: Role of RD1 in virulence of tubercle bacilli journal October 2002
JPred4: a protein secondary structure prediction server journal April 2015
Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0 journal October 2003
Scaling and assessment of data quality journal December 2005
Distributive Conjugal Transfer in Mycobacteria Generates Progeny with Meiotic-Like Genome-Wide Mosaicism, Allowing Mapping of a Mating Identity Locus journal July 2013
Inference of Macromolecular Assemblies from Crystalline State journal September 2007
XDS journal January 2010
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase journal December 2015
Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion journal April 2015
The HHpred interactive server for protein homology detection and structure prediction journal July 2005
Systematic Genetic Nomenclature for Type VII Secretion Systems journal October 2009
A Mycobacterium ESX-1–Secreted Virulence Factor with Unique Requirements for Export journal January 2007
Influence of ESAT-6 Secretion System 1 (RD1) of Mycobacterium tuberculosis on the Interaction between Mycobacteria and the Host Immune System journal March 2005
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation: ESX-5 of M. tuberculosis journal February 2012
Genome-Wide Transposon Mutagenesis Indicates that Mycobacterium marinum Customizes Its Virulence Mechanisms for Survival and Replication in Different Hosts journal February 2015
Fitting molecular fragments into electron density journal December 2007
The TOPCONS web server for consensus prediction of membrane protein topology and signal peptides journal May 2015
SAD phasing using iodide ions in a high-throughput structural genomics environment journal February 2011
A short history of SHELX journal December 2007
Disclosure of the mycobacterial outer membrane: Cryo-electron tomography and vitreous sections reveal the lipid bilayer structure journal March 2008
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009
Deciphering key features in protein structures with the new ENDscript server journal April 2014
Composition of the type VII secretion system membrane complex: Composition of the T7S membrane complex journal August 2012
Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis journal September 2013
Features and development of Coot journal March 2010
N-Terminal clustering of the O-glycosylation sites in the Mycobacterium tuberculosis lipoprotein SodC journal October 2008
REFMAC 5 for the refinement of macromolecular crystal structures journal March 2011
Enzymatic Assembly of Overlapping DNA Fragments book May 2011
X-ray crystal structure of the streptococcal specific phage lysin PlyC journal July 2012
ESX‐1‐mediated translocation to the cytosol controls virulence of mycobacteria journal April 2012
Correlation of Phenotypic Profiles Using Targeted Proteomics Identifies Mycobacterial Esx-1 Substrates journal August 2014
Optimal description of a protein structure in terms of multiple groups undergoing TLS motion journal March 2006
Pfam: the protein families database journal November 2013
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Phaser crystallographic software journal July 2007
C-Terminal Signal Sequence Promotes Virulence Factor Secretion in Mycobacterium tuberculosis journal September 2006
A synergistic approach to protein crystallization: Combination of a fixed-arm carrier with surface entropy reduction journal January 2010
Exploring the gas access routes in a [NiFeSe] hydrogenase using crystals pressurized with krypton and oxygen journal August 2020
Computational studies of polyurethanases from Pseudomonas journal January 2021
PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome journal December 2019
Cryo-EM structure of the respiratory syncytial virus RNA polymerase journal January 2020
Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor journal August 1997
Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity journal August 2022
Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium journal September 2018
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion journal September 2020
Host ANP32A mediates the assembly of the influenza virus replicase journal November 2020
Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) Protein Domains Target LipY Lipases of Pathogenic Mycobacteria to the Cell Surface via the ESX-5 Pathway journal April 2011
The specialized secretory apparatus ESX-1 is essential for DNA transfer inMycobacterium smegmatis journal July 2008
Characterization of a Mycobacterium tuberculosis ESX-3 Conditional Mutant: Essentiality and Rescue by Iron and Zinc journal August 2009
Mycobacterial Esx-3 Requires Multiple Components for Iron Acquisition journal May 2014

Cited By (5)

Functional analysis of the EsaB component of the Staphylococcus aureus Type VII secretion system journal December 2017
The structure of the endogenous ESX-3 secretion system journal December 2019
Protease domain and transmembrane domain of the type VII secretion mycosin protease determine system-specific functioning in mycobacteria journal January 2019
Esx Systems and the Mycobacterial Cell Envelope: What's the Connection? journal May 2017
Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes journal November 2016


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