Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834
- Authors:
- more »
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1252343
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Journal Article: Publisher's Accepted Manuscript
- Journal Name:
- Bioorganic and Medicinal Chemistry Letters
- Additional Journal Information:
- Journal Name: Bioorganic and Medicinal Chemistry Letters Journal Volume: 25 Journal Issue: 6; Journal ID: ISSN 0960-894X
- Publisher:
- Elsevier
- Country of Publication:
- United Kingdom
- Language:
- English
Citation Formats
Young, Wendy B., Barbosa, James, Blomgren, Peter, Bremer, Meire C., Crawford, James J., Dambach, Donna, Gallion, Steve, Hymowitz, Sarah G., Kropf, Jeffrey E., Lee, Seung H., Liu, Lichuan, Lubach, Joseph W., Macaluso, Jen, Maciejewski, Pat, Maurer, Brigitte, Mitchell, Scott A., Ortwine, Daniel F., Di Paolo, Julie, Reif, Karin, Scheerens, Heleen, Schmitt, Aaron, Sowell, C. Gregory, Wang, Xiaojing, Wong, Harvey, Xiong, Jin-Ming, Xu, Jianjun, Zhao, Zhongdong, and Currie, Kevin S. Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834. United Kingdom: N. p., 2015.
Web. doi:10.1016/j.bmcl.2015.01.032.
Young, Wendy B., Barbosa, James, Blomgren, Peter, Bremer, Meire C., Crawford, James J., Dambach, Donna, Gallion, Steve, Hymowitz, Sarah G., Kropf, Jeffrey E., Lee, Seung H., Liu, Lichuan, Lubach, Joseph W., Macaluso, Jen, Maciejewski, Pat, Maurer, Brigitte, Mitchell, Scott A., Ortwine, Daniel F., Di Paolo, Julie, Reif, Karin, Scheerens, Heleen, Schmitt, Aaron, Sowell, C. Gregory, Wang, Xiaojing, Wong, Harvey, Xiong, Jin-Ming, Xu, Jianjun, Zhao, Zhongdong, & Currie, Kevin S. Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834. United Kingdom. https://doi.org/10.1016/j.bmcl.2015.01.032
Young, Wendy B., Barbosa, James, Blomgren, Peter, Bremer, Meire C., Crawford, James J., Dambach, Donna, Gallion, Steve, Hymowitz, Sarah G., Kropf, Jeffrey E., Lee, Seung H., Liu, Lichuan, Lubach, Joseph W., Macaluso, Jen, Maciejewski, Pat, Maurer, Brigitte, Mitchell, Scott A., Ortwine, Daniel F., Di Paolo, Julie, Reif, Karin, Scheerens, Heleen, Schmitt, Aaron, Sowell, C. Gregory, Wang, Xiaojing, Wong, Harvey, Xiong, Jin-Ming, Xu, Jianjun, Zhao, Zhongdong, and Currie, Kevin S. 2015.
"Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834". United Kingdom. https://doi.org/10.1016/j.bmcl.2015.01.032.
@article{osti_1252343,
title = {Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834},
author = {Young, Wendy B. and Barbosa, James and Blomgren, Peter and Bremer, Meire C. and Crawford, James J. and Dambach, Donna and Gallion, Steve and Hymowitz, Sarah G. and Kropf, Jeffrey E. and Lee, Seung H. and Liu, Lichuan and Lubach, Joseph W. and Macaluso, Jen and Maciejewski, Pat and Maurer, Brigitte and Mitchell, Scott A. and Ortwine, Daniel F. and Di Paolo, Julie and Reif, Karin and Scheerens, Heleen and Schmitt, Aaron and Sowell, C. Gregory and Wang, Xiaojing and Wong, Harvey and Xiong, Jin-Ming and Xu, Jianjun and Zhao, Zhongdong and Currie, Kevin S.},
abstractNote = {},
doi = {10.1016/j.bmcl.2015.01.032},
url = {https://www.osti.gov/biblio/1252343},
journal = {Bioorganic and Medicinal Chemistry Letters},
issn = {0960-894X},
number = 6,
volume = 25,
place = {United Kingdom},
year = {Sun Mar 01 00:00:00 EST 2015},
month = {Sun Mar 01 00:00:00 EST 2015}
}
Free Publicly Available Full Text
Publisher's Version of Record at https://doi.org/10.1016/j.bmcl.2015.01.032
Other availability
Cited by: 52 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
B-Cell Receptor Signaling Inhibitors for Treatment of Autoimmune Inflammatory Diseases and B-Cell Malignancies
journal, July 2013
- Puri, Kamal D.; Di Paolo, Julie A.; Gold, Michael R.
- International Reviews of Immunology, Vol. 32, Issue 4
Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity
journal, September 2010
- Uckun, Fatih M.; Qazi, Sanjive
- Expert Opinion on Therapeutic Patents, Vol. 20, Issue 11
Kinase inhibitors as drugs for chronic inflammatory and immunological diseases: progress and challenges
journal, June 2008
- Rokosz, Laura L.; Beasley, James R.; Carroll, Carolyn DiIanni
- Expert Opinion on Therapeutic Targets, Vol. 12, Issue 7
X-Linked Agammaglobulinemia and Other Immunoglobulin Deficiencies
journal, April 1994
- Smith, C. I. Edvard; Islam, Khalid B.; Vorechovsky, Igor
- Immunological Reviews, Vol. 138, Issue 1
Ability of the xid gene to prevent autoimmunity in (NZB X NZW)F1 mice during the course of their natural history, after polyclonal stimulation, or following immunization with DNA.
journal, September 1982
- Steinberg, B. J.; Smathers, P. A.; Frederiksen, K.
- Journal of Clinical Investigation, Vol. 70, Issue 3
Bruton’s Tyrosine Kinase Inhibitors: Approaches to Potent and Selective Inhibition, Preclinical and Clinical Evaluation for Inflammatory Diseases and B Cell Malignancies
journal, March 2012
- Lou, Yan; Owens, Timothy D.; Kuglstatter, Andreas
- Journal of Medicinal Chemistry, Vol. 55, Issue 10
Antiarthritis Effect of a Novel Bruton's Tyrosine Kinase (BTK) Inhibitor in Rat Collagen-Induced Arthritis and Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling: Relationships between Inhibition of BTK Phosphorylation and Efficacy
journal, April 2011
- Liu, Lichuan; Di Paolo, Julie; Barbosa, Jim
- Journal of Pharmacology and Experimental Therapeutics, Vol. 338, Issue 1
Differential Oxidation of Two Thiophene-Containing Regioisomers to Reactive Metabolites by Cytochrome P450 2C9
journal, March 2012
- Rademacher, Peter M.; Woods, Caleb M.; Huang, Qingbiao
- Chemical Research in Toxicology, Vol. 25, Issue 4
The health status and quality of life of adults with X-linked agammaglobulinemia
journal, February 2006
- Howard, Vanessa; Greene, Jeffrey M.; Pahwa, Savita
- Clinical Immunology, Vol. 118, Issue 2-3
Ibrutinib and novel BTK inhibitors in clinical development
journal, January 2013
- Akinleye, Akintunde; Chen, Yamei; Mukhi, Nikhil
- Journal of Hematology & Oncology, Vol. 6, Issue 1
Role of Bruton's tyrosine kinase in immunodeficiency
journal, August 1994
- Tsukada, Satoshi; Rawlings, David J.; Witte, Owen N.
- Current Opinion in Immunology, Vol. 6, Issue 4
Bruton's tyrosine kinase as a drug discovery target
journal, January 2008
- Pan, Z.
- Drug News & Perspectives, Vol. 21, Issue 7
Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
journal, July 2011
- Liu, Lichuan; Halladay, Jason S.; Shin, Young
- Drug Metabolism and Disposition, Vol. 39, Issue 10
The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective
journal, June 2000
- Satterthwaite1, Anne B.; Witte1,2, Owen N.
- Immunological Reviews, Vol. 175, Issue 1
Specific Btk inhibition suppresses B cell– and myeloid cell–mediated arthritis
journal, November 2010
- Di Paolo, Julie A.; Huang, Tao; Balazs, Mercedesz
- Nature Chemical Biology, Vol. 7, Issue 1
A Comprehensive Listing of Bioactivation Pathways of Organic Functional Groups
journal, June 2005
- Kalgutkar, Amit; Gardner, Iain; Obach, R.
- Current Drug Metabolism, Vol. 6, Issue 3
X-Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase: X-Ray Crystal Structure of BMX
journal, September 2011
- Muckelbauer, Jodi; Sack, John S.; Ahmed, Nazia
- Chemical Biology & Drug Design, Vol. 78, Issue 5
Genes on the X chromosome affect development of collagen-induced arthritis in mice
journal, December 1993
- Jansson, L.; Holmdahl, R.
- Clinical & Experimental Immunology, Vol. 94, Issue 3