Insights into the structure and function of membrane-integrated processive glycosyltransferases

Bi, Yunchen; Hubbard, Caitlin; Purushotham, Pallinti; Zimmer, Jochen

doi:10.1016/j.sbi.2015.07.008

Title: Insights into the structure and function of membrane-integrated processive glycosyltransferases

Journal Article · Wed Sep 02 00:00:00 EDT 2015 · Current Opinion in Structural Biology

DOI:https://doi.org/10.1016/j.sbi.2015.07.008· OSTI ID:1344504

^[1]; Hubbard, Caitlin ^[1]; Purushotham, Pallinti ^[1]; Zimmer, Jochen ^[1]

Univ. of Virginia, Charlottesville, VA (United States)

Complex carbohydrates perform essential functions in life, including energy storage, cell signaling, protein targeting, quality control, as well as supporting cell structure and stability. Extracellular polysaccharides (EPS) represent mainly structural polymers and are found in essentially all kingdoms of life. For example, EPS are important biofilm and capsule components in bacteria, represent major constituents in cell walls of fungi, algae, arthropods and plants, and modulate the extracellular matrix in vertebrates. Different mechanisms evolved by which EPS are synthesized. In this paper, we review the structures and functions of membrane-integrated processive glycosyltransferases (GTs) implicated in the synthesis and secretion of chitin, alginate, hyaluronan and poly-N-acetylglucosamine (PNAG).

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Research Organization:: Univ. of Virginia, Charlottesville, VA (United States); Energy Frontier Research Centers (EFRC) (United States). Center for Lignocellulose Structure and Formation (CLSF)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0001090

OSTI ID:: 1344504

Alternate ID(s):: OSTI ID: 1250108

Journal Information:: Current Opinion in Structural Biology, Vol. 34; ISSN 0959-440X

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 35 works

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