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Title: Completing the link between exposure science and toxicology for improved environmental health decision making: The aggregate exposure pathway framework

Here, driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health, the field of exposure science is undergoing a rapid transition from a field of observation to a field of prediction. Deployment of an organizational and predictive framework for exposure science analogous to the “systems approaches” used in the biological sciences is a necessary step in this evolution. Here we propose the aggregate exposure pathway (AEP) concept as the natural and complementary companion in the exposure sciences to the adverse outcome pathway (AOP) concept in the toxicological sciences. Aggregate exposure pathways offer an intuitive framework to organize exposure data within individual units of prediction common to the field, setting the stage for exposure forecasting. Looking farther ahead, we envision direct linkages between aggregate exposure pathways and adverse outcome pathways, completing the source to outcome continuum for more meaningful integration of exposure assessment and hazard identification. Together, the two frameworks form and inform a decision-making framework with the flexibility for risk-based, hazard-based, or exposure-based decision making.
 [1] ;  [2] ;  [2] ;  [3] ;  [4] ;  [5] ;  [4] ;  [4] ;  [4] ;  [4] ;  [5] ;  [4] ;  [4] ;  [4]
  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Oregon State Univ., Corvallis, OR (United States)
  2. U.S. Environmental Protection Agency, Durham, NC (United States)
  3. Oak Ridge Institute for Science and Education, Oak Ridge, TN (United States)
  4. Oregon State Univ., Corvallis, OR (United States)
  5. Oregon State Univ., Corvallis, OR (United States); Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Publication Date:
OSTI Identifier:
Report Number(s):
Journal ID: ISSN 0013-936X
Grant/Contract Number:
P30 ES000210; AC05-7601830
Accepted Manuscript
Journal Name:
Environmental Science and Technology
Additional Journal Information:
Journal Volume: 136; Journal Issue: 2; Journal ID: ISSN 0013-936X
American Chemical Society (ACS)
Research Org:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org:
Country of Publication:
United States