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Title: Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging

Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues. In various embodiments, the nanoparticle composition includes at least one of: a nanoparticle, a polymer layer, and a binding agent, such that the polymer layer coats the nanoparticle and is for example a polyethylene glycol, a polyelectrolyte, an anionic polymer, or a cationic polymer, and such that the binding agent that specifically binds the cells or the tissue. Methods, compositions, systems, devices and kits are provided for identifying potential therapeutic agents in a model using the nanoparticle composition and spatial frequency heterodyne imaging.
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
1247995
Report Number(s):
9,316,645
13/645,938
DOE Contract Number:
FG02-08ER15937
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Oct 05
Research Org:
BROWN UNIVERSITY, Providence, RI (United States) RHODE ISLAND HOSPITAL, Providence, RI (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY