Preparation of 4-amino-2,4-dioxobutanoic acid

Unkefer, Pat J.; Martinez, Rodolfo A.; Glass, David R.

Title: Preparation of 4-amino-2,4-dioxobutanoic acid

Patent · Tue Mar 22 00:00:00 EDT 2016

OSTI ID:1243345

Unkefer, Pat J.; Martinez, Rodolfo A.; Glass, David R.

A process for synthesizing 4-amino-2,4-dioxobutanoate involves reacting a dialkyl oxalate with an alkoxide in ethanol to form a reaction mixture, and afterward adding an alkyl cyano acetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl 2-cyano-3-hydroxy-butenedioate, and then isolating the diethyl 2-cyano-3-hydroxy-butenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with an aqueous hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoate. The 4-amino-2,4-dioxobutanoate may be acidified into 4-amino-2,4-dioxobutanoic acid.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-06NA25396

Assignee:: Los Alamos National Security, LLC (Los Alamos, NM) New Mexico Highlands University (Las Vegas, NM)

Patent Number(s):: 9,290,443

Application Number:: 14/489,329

OSTI ID:: 1243345

Resource Relation:: Patent File Date: 2014 Sep 17

Country of Publication:: United States

Language:: English

References (30)

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