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Title: Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection

Cell culture study combing a mathematical model and computer simulation quantifies the anti-hepatitis C virus drug efficacy at any concentrations and any combinations in preclinical settings, and can obtain rich basic evidences for selecting optimal treatments prior to costly clinical trials.
Authors:
 [1] ;  [2] ;  [2] ;  [3] ;  [4] ;  [5] ;  [6] ;  [7]
  1. Kanazawa Univ. (Japan). School of Medicine
  2. National Inst. of Infectious Diseases, Tokyo (Japan); Tokyo Univ. of Science, Chiba (Japan)
  3. Nagoya City Univ. Graduate School of Medicinal Sciences (Japan)
  4. National Inst. of Infectious Diseases, Tokyo (Japan)
  5. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  6. Kyushu Univ. (Japan); Japan Science and Technology Agency (JST), Saitama (Japan). PRESTO
  7. National Inst. of Infectious Diseases, Tokyo (Japan); Tokyo Univ. of Science, Chiba (Japan); Japan Science and Technology Agency (JST), Saitama (Japan)
Publication Date:
OSTI Identifier:
1242919
Report Number(s):
LA-UR-16-21895
DOE Contract Number:
AC52-06NA25396
Resource Type:
Technical Report
Research Org:
Los Alamos National Laboratory (LANL)
Sponsoring Org:
USDOE; National Institutes of Health
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES Biological Science