Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans

Garces, Fernando; Lee, Jeong Hyun; de Val, Natalia; Torrents de la Pena, Alba; Kong, Leopold; Puchades, Cristina; Hua, Yuanzi; Stanfield, Robyn L.; Burton, Dennis R.; Moore, John P.; Sanders, Rogier W.; Ward, Andrew B.; Wilson, Ian A.

doi:10.1016/j.immuni.2015.11.007

Title: Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans

Journal Article · Tue Dec 01 00:00:00 EST 2015 · Immunity

DOI:https://doi.org/10.1016/j.immuni.2015.11.007· OSTI ID:1335995

Garces, Fernando; Lee, Jeong Hyun; de Val, Natalia; Torrents de la Pena, Alba; Kong, Leopold; Puchades, Cristina; Hua, Yuanzi; Stanfield, Robyn L.; Burton, Dennis R.; Moore, John P.; Sanders, Rogier W.; Ward, Andrew B.; Wilson, Ian A.

View Journal Article

Cite

Export

Save

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); NIH NIGMS; European Research Council (ERC)

Grant/Contract Number:: AC02-05CH11231; AC02-06CH11357; U54 GM094586; ERC-StG-2011–280829-SHEV; P01 AI082362; P01 AI110657; R37 AI036082; UM1 AI00663

OSTI ID:: 1335995

Alternate ID(s):: OSTI ID: 1235476; OSTI ID: 1243363

Journal Information:: Immunity, Journal Name: Immunity Vol. 43 Journal Issue: 6; ISSN 1074-7613

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 162 works

Citation information provided by
Web of Science

References (35)

Antibody responses to envelope glycoproteins in HIV-1 infection Burton, Dennis R.; Mascola, John R. Nature Immunology, Vol. 16, Issue 6 https://doi.org/10.1038/ni.3158	journal	May 2015
Structure and immune recognition of trimeric pre-fusion HIV-1 Env Pancera, Marie; Zhou, Tongqing; Druz, Aliaksandr Nature, Vol. 514, Issue 7523 https://doi.org/10.1038/nature13808	journal	October 2014
On the use of the merging R factor as a quality indicator for X-ray data Weiss, M. S.; Hilgenfeld, R. Journal of Applied Crystallography, Vol. 30, Issue 2 https://doi.org/10.1107/S0021889897003907	journal	April 1997
Accessing the Kabat antibody sequence database by computer: ACCESSING THE KABAT DATABASE BY COMPUTER Martin, Andrew C. R. Proteins: Structure, Function, and Bioinformatics, Vol. 25, Issue 1 https://doi.org/10.1002/(SICI)1097-0134(199605)25:1<130::AID-PROT11>3.0.CO;2-L	journal	May 1996
A clustering approach to multireference alignment of single-particle projections in electron microscopy Sorzano, C. O. S.; Bilbao-Castro, J. R.; Shkolnisky, Y. Journal of Structural Biology, Vol. 171, Issue 2 https://doi.org/10.1016/j.jsb.2010.03.011	journal	August 2010
Frequency and Phenotype of Human Immunodeficiency Virus Envelope-Specific B Cells from Patients with Broadly Cross-Neutralizing Antibodies Doria-Rose, N. A.; Klein, R. M.; Manion, M. M. Journal of Virology, Vol. 83, Issue 1 https://doi.org/10.1128/JVI.01583-08	journal	October 2008
Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies Gao, Feng; Bonsignori, Mattia; Liao, Hua-Xin Cell, Vol. 158, Issue 3 https://doi.org/10.1016/j.cell.2014.06.022	journal	July 2014
Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans Julien, Jean-Philippe; Sok, Devin; Khayat, Reza PLoS Pathogens, Vol. 9, Issue 5 https://doi.org/10.1371/journal.ppat.1003342	journal	May 2013
Rapid development of broadly influenza neutralizing antibodies through redundant mutations Pappas, Leontios; Foglierini, Mathilde; Piccoli, Luca Nature, Vol. 516, Issue 7531 https://doi.org/10.1038/nature13764	journal	October 2014
Broad neutralization coverage of HIV by multiple highly potent antibodies Walker, Laura M.; Huber, Michael; Doores, Katie J. Nature, Vol. 477, Issue 7365 https://doi.org/10.1038/nature10373	journal	September 2011
A New Generation of the IMAGIC Image Processing System van Heel, Marin; Harauz, George; Orlova, Elena V. Journal of Structural Biology, Vol. 116, Issue 1 https://doi.org/10.1006/jsbi.1996.0004	journal	January 1996
Coot model-building tools for molecular graphics Emsley, Paul; Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132 https://doi.org/10.1107/S0907444904019158	journal	November 2004
DoG Picker and TiltPicker: Software tools to facilitate particle selection in single particle electron microscopy Voss, N. R.; Yoshioka, C. K.; Radermacher, M. Journal of Structural Biology, Vol. 166, Issue 2 https://doi.org/10.1016/j.jsb.2009.01.004	journal	May 2009
Appion: An integrated, database-driven pipeline to facilitate EM image processing Lander, Gabriel C.; Stagg, Scott M.; Voss, Neil R. Journal of Structural Biology, Vol. 166, Issue 1 https://doi.org/10.1016/j.jsb.2009.01.002	journal	April 2009
Automated molecular microscopy: The new Leginon system Suloway, Christian; Pulokas, James; Fellmann, Denis Journal of Structural Biology, Vol. 151, Issue 1 https://doi.org/10.1016/j.jsb.2005.03.010	journal	July 2005
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. McKean, D.; Huppi, K.; Bell, M. Proceedings of the National Academy of Sciences, Vol. 81, Issue 10 https://doi.org/10.1073/pnas.81.10.3180	journal	May 1984
Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer Julien, J. -P.; Cupo, A.; Sok, D. Science, Vol. 342, Issue 6165 https://doi.org/10.1126/science.1245625	journal	October 2013
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies Mouquet, H.; Scharf, L.; Euler, Z. Proceedings of the National Academy of Sciences, Vol. 109, Issue 47 https://doi.org/10.1073/pnas.1217207109	journal	October 2012
Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer Lyumkis, D.; Julien, J. -P.; de Val, N. Science, Vol. 342, Issue 6165 https://doi.org/10.1126/science.1245627	journal	October 2013
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield Pejchal, R.; Doores, K. J.; Walker, L. M. Science, Vol. 334, Issue 6059 https://doi.org/10.1126/science.1213256	journal	October 2011
Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies Garces, Fernando; Sok, Devin; Kong, Leopold Cell, Vol. 159, Issue 1 https://doi.org/10.1016/j.cell.2014.09.009	journal	September 2014
The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies Sok, Devin; Laserson, Uri; Laserson, Jonathan PLoS Pathogens, Vol. 9, Issue 11 https://doi.org/10.1371/journal.ppat.1003754	journal	November 2013
Factors Associated with the Development of Cross-Reactive Neutralizing Antibodies during Human Immunodeficiency Virus Type 1 Infection Sather, D. N.; Armann, J.; Ching, L. K. Journal of Virology, Vol. 83, Issue 2 https://doi.org/10.1128/JVI.02036-08	journal	November 2008
The Effect of Antigen Dose and Time after Immunization on the Amount and Affinity of Anti-Hapten Antibody Goidl, Edmond A.; Paul, William E.; Siskind, Gregory W. The Journal of Immunology, Vol. 100, Issue 2 https://doi.org/10.4049/jimmunol.100.2.371	journal	February 1968
Variations in Affinities of Antibodies during the Immune Response ^* Eisen, Herman N.; Siskind, Gregory W. Biochemistry, Vol. 3, Issue 7 https://doi.org/10.1021/bi00895a027	journal	July 1964
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120 Kong, Leopold; Lee, Jeong Hyun; Doores, Katie J. Nature Structural & Molecular Biology, Vol. 20, Issue 7 https://doi.org/10.1038/nsmb.2594	journal	May 2013
Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV Sok, D.; Doores, K. J.; Briney, B. Science Translational Medicine, Vol. 6, Issue 236 https://doi.org/10.1126/scitranslmed.3008104	journal	May 2014
[20] Processing of X-ray diffraction data collected in oscillation mode Otwinowski, Zbyszek; Minor, Wladek Macromolecular Crystallography Part A, 307-326 https://doi.org/10.1016/S0076-6879(97)76066-X	book	January 1997
Maturation of the immune response in germinal centers Berek, C.; Berger, A.; Apel, M. Cell, Vol. 67, Issue 6 https://doi.org/10.1016/0092-8674(91)90289-B	journal	December 1991
Global indicators of X-ray data quality Weiss, Manfred S. Journal of Applied Crystallography, Vol. 34, Issue 2 https://doi.org/10.1107/S0021889800018227	journal	April 2001
Complete Nucleotide Sequences of Functional Clones of the AIDS Virus Ratner, Lee; Fisher, Amanda; Jagodzinski, Linda L. AIDS Research and Human Retroviruses, Vol. 3, Issue 1 https://doi.org/10.1089/aid.1987.3.57	journal	January 1987
EMAN: Semiautomated Software for High-Resolution Single-Particle Reconstructions Ludtke, Steven J.; Baldwin, Philip R.; Chiu, Wah Journal of Structural Biology, Vol. 128, Issue 1 https://doi.org/10.1006/jsbi.1999.4174	journal	December 1999
Insights into the trimeric HIV-1 envelope glycoprotein structure Ward, Andrew B.; Wilson, Ian A. Trends in Biochemical Sciences, Vol. 40, Issue 2 https://doi.org/10.1016/j.tibs.2014.12.006	journal	February 2015
Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120 Chen, L.; Do Kwon, Y.; Zhou, T. Science, Vol. 326, Issue 5956 https://doi.org/10.1126/science.1175868	journal	November 2009

Similar Records

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

Journal Article · Tue Aug 22 00:00:00 EDT 2017 · Cell Reports · OSTI ID:1335995

Torrents de la Peña, Alba; Julien, Jean-Philippe; de Taeye, Steven W.; +26 more

Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor

Journal Article · Fri Apr 01 00:00:00 EDT 2016 · Immunity · OSTI ID:1335995

Kong, Leopold; Ju, Bin; Chen, Yajing; +25 more

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

Journal Article · Fri Sep 25 00:00:00 EDT 2015 · Nature Communications · OSTI ID:1335995

Lee, Jeong Hyun; Leaman, Daniel P.; Kim, Arthur S.; +17 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES

Title: Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans

Citation Formats

References (35)

Similar Records

Related Subjects