Analysis of clock-regulated genes in Neurospora reveals widespread posttranscriptional control of metabolic potential

Hurley, Jennifer M.; Dasgupta, Arko; Emerson, Jillian M.; Zhou, Xiaoying; Ringelberg, Carol S.; Knabe, Nicole; Lipzen, Anna M.; Lindquist, Erika A.; Daum, Christopher G.; Barry, Kerrie W.; Grigoriev, Igor V.; Smith, Kristina M.; Galagan, James E.; Bell-Pedersen, Deborah; Freitag, Michael; Cheng, Chao; Loros, Jennifer J.; Dunlap, Jay C.

doi:10.1073/pnas.1418963111

Title: Analysis of clock-regulated genes in Neurospora reveals widespread posttranscriptional control of metabolic potential

Journal Article · Fri Oct 31 00:00:00 EDT 2014 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.1418963111· OSTI ID:1235141

Hurley, Jennifer M. ^[1]; Dasgupta, Arko ^[1]; Emerson, Jillian M. ^[1]; Zhou, Xiaoying ^[1]; Ringelberg, Carol S. ^[1]; Knabe, Nicole ^[1]; Lipzen, Anna M. ^[2]; Lindquist, Erika A. ^[2]; Daum, Christopher G. ^[2]; Barry, Kerrie W. ^[2]; Grigoriev, Igor V. ^[2]; Smith, Kristina M. ^[3]; Galagan, James E. ^[4]; Bell-Pedersen, Deborah ^[5]; Freitag, Michael ^[3]; Cheng, Chao ^[1]; Loros, Jennifer J. ^[6]; Dunlap, Jay C. ^[1]

Department of Genetics, Geisel School of Medicine, Hanover, NH 03755,
US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598,
Department of Biochemistry and Biophysics, Center of Genome Research and Biocomputing, Oregon State University, Corvallis, OR 97331,
Departments of dBiomedical Engineering and, Microbiology, Boston University, Boston, MA 02215,
Department of Biology, Texas A&,M University, College Station, TX 77843, and
Department of Genetics, Geisel School of Medicine, Hanover, NH 03755,, Department of Biochemistry, Geisel School of Medicine, Hanover, NH 03755

Significance Circadian clocks regulate gene expression levels to allow an organism to anticipate environmental conditions. These clocks reside in all the major branches of life and confer a competitive advantage to the organisms that maintain them. The clock in the fungus Neurospora crassa is an excellent model for basic understanding of core circadian architecture as well as for filamentous fungi. Here, we identify genes whose expression is clock regulated; indeed, as much as 40% of the transcriptome may be clock regulated, broadly directing daytime catabolism and nighttime growth. Both transcriptional control and posttranscriptional regulation play major roles in control of cycling transcripts such that DNA binding of transcription factors alone appears insufficient to set the phase of circadian transcription.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1235141

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Journal Name: Proceedings of the National Academy of Sciences of the United States of America Vol. 111 Journal Issue: 48; ISSN 0027-8424

Publisher:: Proceedings of the National Academy of SciencesCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 95 works

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