Permeability barrier of Gram-negative cell envelopes and approaches to bypass it

Zgurskaya, Helen I.; López, Cesar A.; Gnanakaran, Sandrasegaram

doi:10.1021/acsinfecdis.5b00097

Title: Permeability barrier of Gram-negative cell envelopes and approaches to bypass it

Journal Article · Fri Sep 18 00:00:00 EDT 2015 · ACS Infectious Diseases

DOI:https://doi.org/10.1021/acsinfecdis.5b00097· OSTI ID:1234255

Zgurskaya, Helen I. ^[1]; López, Cesar A. ^[2]; Gnanakaran, Sandrasegaram ^[2]

Univ. of Oklahoma, Norman, OK (United States)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Gram-negative bacteria are intrinsically resistant to many antibiotics. Species that have acquired multidrug resistance and cause infections that are effectively untreatable present a serious threat to public health. The problem is broadly recognized and tackled at both the fundamental and applied levels. This article summarizes current advances in understanding the molecular bases of the low permeability barrier of Gram-negative pathogens, which is the major obstacle in discovery and development of antibiotics effective against such pathogens. Gaps in knowledge and specific strategies to break this barrier and to achieve potent activities against difficult Gram-negative bacteria are also discussed.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AI052293; HDTRA1-14-1-0019; AC52-06NA25396

OSTI ID:: 1234255

Report Number(s):: LA-UR-15-27220

Journal Information:: ACS Infectious Diseases, Vol. 1, Issue 11; ISSN 2373-8227

Country of Publication:: United States

Language:: English

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Cited by: 341 works

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