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Title: Tools for the microbiome. Nano and beyond

Here, the microbiome presents great opportunities for understanding and improving the world around us and elucidating the interactions that compose it. The microbiome also poses tremendous challenges for mapping and manipulating the entangled networks of interactions among myriad diverse organisms. Here, we describe the opportunities, technical needs, and potential approaches to address these challenges, based on recent and upcoming advances in measurement and control at the nanoscale and beyond. Moreover, these technical needs will provide the basis for advancing the largely descriptive studies of the microbiome to the theoretical and mechanistic understandings that will underpin the discipline of microbiome engineering. We anticipate that the new tools and methods developed will also be more broadly useful in environmental monitoring, medicine, forensics, and other areas.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [5] ;  [6] ;  [7] ;  [8] ;  [9] ;  [6] ;  [10] ;  [10] ;  [6] ;  [11] ;  [12] ;  [13] ;  [4] ;  [14] ;  [10] ;  [10] more »;  [9] ;  [10] « less
  1. Univ. of Michigan, Ann Arbor, MI (United States)
  2. Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
  3. Marine Biological Lab., Woods Hole, MA (United States)
  4. The Kavli Foundation, Oxnard, CA (United States)
  5. Harvard Medical School, Boston, MA (United States); Harvard Univ., Boston, MA (United States)
  6. Univ. of California, San Diego, La Jolla, CA (United States)
  7. Univ. of Southern California, Los Angeles, CA (United States)
  8. Argonne National Lab. (ANL), Argonne, IL (United States); Univ. of Chicago, Chicago, IL (United States)
  9. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  10. Univ. of California, Los Angeles, CA (United States)
  11. Stanford Univ., Stanford, CA (United States)
  12. Univ. of Hawaii-Manoa, Honolulu, HI (United States)
  13. Harvard Univ., Boston, MA (United States); Harvard Medical School, Boston, MA (United States)
  14. Center for Marine Cytometry, Concrete, WA (United States); Univ. de Concepcion, Concepcion (Chile)
Publication Date:
OSTI Identifier:
1233975
Report Number(s):
PNNL-SA-115178
Journal ID: ISSN 1936-0851; KP1601010
Grant/Contract Number:
AC05-76RL01830; OBER; PNNL - DE-AC06-76RL01830
Type:
Published Article
Journal Name:
ACS Nano
Additional Journal Information:
Journal Volume: 10; Journal Issue: 1; Journal ID: ISSN 1936-0851
Publisher:
American Chemical Society
Research Org:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES