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Title: Dimeric c-di-GMP Is Required for Post-translational Regulation of Alginate Production in Pseudomonas aeruginosa

Journal Article · · Journal of Biological Chemistry
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Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
DOE Contract Number:
SC00112704
OSTI ID:
1229019
Report Number(s):
BNL-111094-2015-JA
Journal Information:
Journal of Biological Chemistry, Vol. 290, Issue 20; ISSN 0021-9258
Publisher:
American Society for Biochemistry and Molecular Biology
Country of Publication:
United States
Language:
English

References (56)

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Synthase-dependent exopolysaccharide secretion in Gram-negative bacteria journal February 2013
Structural polymorphism of c-di-GMP bound to an EAL domain and in complex with a type II PilZ-domain protein journal September 2012
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FimX, a Multidomain Protein Connecting Environmental Signals to Twitching Motility in Pseudomonas aeruginosa journal December 2003
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The response threshold of Salmonella PilZ domain proteins is determined by their binding affinities for c-di-GMP : c-di-GMP binding affinities of PilZ domain proteins journal November 2012
The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix: Polysaccharides of the P. aeruginosa biofilm matrix journal December 2011
Solution Structure of the PilZ Domain Protein PA4608 Complex with Cyclic di-GMP Identifies Charge Clustering as Molecular Readout journal February 2011
PilZ domain is part of the bacterial c-di-GMP binding protein journal October 2005
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Inference of Macromolecular Assemblies from Crystalline State journal September 2007
Understanding the control of Pseudomonas aeruginosa alginate synthesis and the prospects for management of chronic infections in cystic fibrosis: P. aeruginosa pathogenesis journal February 2005
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Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence journal February 2006
Identification of FleQ from Pseudomonas aeruginosa as a c-di-GMP-responsive transcription factor journal July 2008
The second messenger bis-(3'-5')-cyclic-GMP and its PilZ domain-containing receptor Alg44 are required for alginate biosynthesis in Pseudomonas aeruginosa journal August 2007
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Oligomer Formation of the Bacterial Second Messenger c-di-GMP: Reaction Rates and Equilibrium Constants Indicate a Monomeric State at Physiological Concentrations journal December 2011
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Structural Basis for c-di-GMP-Mediated Inside-Out Signaling Controlling Periplasmic Proteolysis journal February 2011
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Roles of Cyclic Diguanylate in the Regulation of Bacterial Pathogenesis journal October 2007
Polysaccharides serve as scaffold of biofilms formed by mucoid Pseudomonas aeruginosa journal July 2012
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Alginate is not a significant component of the extracellular polysaccharide matrix of PA14 and PAO1 Pseudomonas aeruginosa biofilms journal June 2003
Structure of PP4397 Reveals the Molecular Basis for Different c-di-GMP Binding Modes by Pilz Domain Proteins journal April 2010
Type IV Pilus Assembly in Pseudomonas aeruginosa over a Broad Range of Cyclic di-GMP Concentrations journal June 2012
A new modification of the carbazole analysis: Application to heteropolysaccharides journal September 1968
Membrane topology and roles of Pseudomonas aeruginosa Alg8 and Alg44 in alginate polymerization journal June 2008
Structure of E. coli 5′-methylthioadenosine/S-adenosylhomocysteine Nucleosidase Reveals Similarity to the Purine Nucleoside Phosphorylases journal October 2001
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PilZ Domain Proteins Bind Cyclic Diguanylate and Regulate Diverse Processes in Vibrio cholerae journal February 2007
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Exploring the gas access routes in a [NiFeSe] hydrogenase using crystals pressurized with krypton and oxygen journal August 2020
Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation journal February 2021
Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard. journalarticle January 2008
Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein-protein interaction text January 2013
Structural basis of activity and allosteric control of diguanylate cyclase text January 2004
PilZ domain proteins bind cyclic diguanylate and regulate diverse processes in Vibrio cholerae text January 2007
PHENIX: a comprehensive Python-based system for macromolecular structure solution. text January 2010
Oligomer formation of the bacterial second messenger c-di-GMP : reaction rates and equilibrium constants indicate a monomeric state at physiological concentrations text January 2012

Cited By (25)

Recent advances in understanding Pseudomonas aeruginosa as a pathogen journal January 2017
Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in P seudomonas aeruginosa: SadC regulates alginate production journal February 2016
Tlr1612 is the major repressor of cell aggregation in the light-color-dependent c-di-GMP signaling network of Thermosynechococcus vulcanus journal March 2018
AraC-like transcriptional activator CuxR binds c-di-GMP by a PilZ-like mechanism to regulate extracellular polysaccharide production journal May 2017
Biological function of a polysaccharide degrading enzyme in the periplasm journal November 2016
Structures of the activator of K. pneumonia biofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding journal August 2016
Novel dual regulators of Pseudomonas aeruginosa essential for productive biofilms and virulence journal July 2018
Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection journal March 2017
Activation Mechanism and Cellular Localization of Membrane-Anchored Alginate Polymerase in Pseudomonas aeruginosa journal March 2017
Evolutionary forecasting of phenotypic and genetic outcomes of experimental evolution in Pseudomonas journal March 2021
Structural analyses unravel the molecular mechanism of cyclic di-GMP regulation of bacterial chemotaxis via a PilZ adaptor protein journal November 2017
The Role of Alginate in Bacterial Biofilm Formation book January 2019
Orchestrated delivery of Legionella effectors by the Icm/Dot secretion system posted_content January 2019
Structural conservation and diversity of PilZ-related domains posted_content October 2019
Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules journal January 2016
Molecular aspects of bacterial nanocellulose biosynthesis journal March 2019
Identification of genes affecting alginate biosynthesis in Pseudomonas fluorescens by screening a transposon insertion library journal January 2017
CRISPR interference to interrogate genes that control biofilm formation in Pseudomonas fluorescens journal November 2019
The PilZ domain of MrkH represents a novel DNA binding motif journal September 2016
Analysis of the alginate O-acetylation machinery in Pseudomonas aeruginosa journal January 2020
Direct activation of a phospholipase by cyclic GMP-AMP in El Tor Vibrio cholerae journal June 2018
MotI (DgrA) acts as a molecular clutch on the flagellar stator protein MotA in Bacillus subtilis journal December 2017
Emerging paradigms for PilZ domain-mediated C-di-GMP signaling journal February 2019
A Cyclic di-GMP-binding Adaptor Protein Interacts with Histidine Kinase to Regulate Two-component Signaling journal July 2016
Diversity of Cyclic Di-GMP-Binding Proteins and Mechanisms journal June 2015

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