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Title: Genetic Background Modulates lncRNA-Coordinated Tissue Response to Low Dose Ionizing Radiation

Journal Article · · International Journal of Genomics
DOI:https://doi.org/10.1155/2015/461038· OSTI ID:1227911
 [1];  [1];  [1];  [1];  [1];  [1]
  1. Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road MS977, Berkeley, CA 94720, USA
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Long noncoding RNAs (lncRNAs) are emerging as key regulators of diverse cell functions and processes. However, the relevance of lncRNAs in the cell and tissue response to ionizing radiation has not yet been characterized. Here we used microarray profiling to determine lncRNA and mRNA expression in mammary glands of BALB/c and SPRET/EiJ mice after low-dose ionizing radiation (LDIR) exposure. We found that unirradiated mammary tissues of these strains differed significantly in baseline expressions of 290 lncRNAs. LDIR exposure (10 cGy) induced a significant change in the expression of many lncRNAs. The vast majority of lncRNAs identified to be differentially expressed after LDIR in either BALB/c or SPRET/EiJ had a significantly correlated expression pattern with at least one LDIR responsive mRNA. Functional analysis revealed that the response to LDIR in BALB/c mice is highly dynamic with enrichment for genes involved in tissue injury, inflammatory responses, and mammary gland development at 2, 4, and 8 weeks after LDIR, respectively. Our study demonstrates that genetic background strongly influences the expression of lncRNAs and their response to radiation and that lncRNAs may coordinate the tissue response to LDIR exposure via regulation of coding mRNAs.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
Grant/Contract Number:
AC02-05CH11231
OSTI ID:
1227911
Alternate ID(s):
OSTI ID: 1209505; OSTI ID: 1512170
Journal Information:
International Journal of Genomics, Journal Name: International Journal of Genomics Vol. 2015; ISSN 2314-436X
Publisher:
Hindawi Publishing CorporationCopyright Statement
Country of Publication:
Egypt
Language:
English
Citation Metrics:
Cited by: 6 works
Citation information provided by
Web of Science

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Figures / Tables (4)

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.