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Title: Magnetic relaxometry as applied to sensitive cancer detection and localization

Here we describe superparamagnetic relaxometry (SPMR), a technology that utilizes highly sensitive magnetic sensors and superparamagnetic nanoparticles for cancer detection. Using SPMR, we sensitively and specifically detect nanoparticles conjugated to biomarkers for various types of cancer. SPMR offers high contrast In SPMR measurements, a brief magnetizing pulse is used to align superparamagnetic nanoparticles of a discrete size. Following the pulse, an array of superconducting quantum interference detectors (SQUID) sensors detect the decaying magnetization field. NP size is chosen so that, when bound, the induced field decays in seconds. They are functionalized with specific biomarkers and incubated with cancer cells As a result, superparamagnetic NPs developed here have small size dispersion. Cell incubation studies measure specificity for different cell lines and antibodies with very high contrast.
Authors:
 [1] ;  [1] ;  [1] ;  [1] ;  [2] ;  [3] ;  [4] ;  [1] ;  [1] ;  [3] ;  [1]
  1. Senior Scientific LLC, Albuquerque, NM (United States)
  2. Univ. of New Mexico School of Medicine, Albuquerque, NM (United States)
  3. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
  4. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Publication Date:
OSTI Identifier:
1227725
Report Number(s):
LA-UR-15-21938; SAND-2015-6922J
Journal ID: ISSN 0013-5585
Grant/Contract Number:
AC52-06NA25396; AC04-94AL85000; SC0008810
Type:
Accepted Manuscript
Journal Name:
Biomedizinische Technik
Additional Journal Information:
Journal Volume: 60; Journal Issue: 5; Journal ID: ISSN 0013-5585
Publisher:
De Gruyter
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); AC52-06NA25396
Sponsoring Org:
USDOE National Nuclear Security Administration (NNSA)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; SQUID; magnetic relaxometry; nanoparticles; cancer; 77 NANOSCIENCE AND NANOTECHNOLOGY; magnetic; relaxometry