SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

Huang, Wenlin; Ojo, Kayode K.; Zhang, Zhongsheng; Rivas, Kasey; Vidadala, Rama Subba Rao; Scheele, Suzanne; DeRocher, Amy E.; Choi, Ryan; Hulverson, Matthew A.; Barrett, Lynn K.; Bruzual, Igor; Siddaramaiah, Latha Kallur; Kerchner, Keshia M.; Kurnick, Matthew D.; Freiberg, Gail M.; Kempf, Dale; Hol, Wim G. J.; Merritt, Ethan A.; Neckermann, Georg; de Hostos, Eugenio L.; Isoherranen, Nina; Maly, Dustin J.; Parsons, Marilyn; Doggett, J. Stone; Van Voorhis, Wesley C.; Fan, Erkang

doi:10.1021/acsmedchemlett.5b00319

Title: SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

Journal Article · Mon Oct 26 00:00:00 EDT 2015 · ACS Medicinal Chemistry Letters

DOI:https://doi.org/10.1021/acsmedchemlett.5b00319· OSTI ID:1227228

Huang, Wenlin ^[1]; Ojo, Kayode K. ^[2]; Zhang, Zhongsheng ^[1]; Rivas, Kasey ^[2]; Vidadala, Rama Subba Rao ^[3]; Scheele, Suzanne ^[4]; DeRocher, Amy E. ^[4]; Choi, Ryan ^[2]; Hulverson, Matthew A. ^[2]; Barrett, Lynn K. ^[2]; Bruzual, Igor ^[5]; Siddaramaiah, Latha Kallur ^[1]; Kerchner, Keshia M. ^[1]; Kurnick, Matthew D. ^[6]; Freiberg, Gail M. ^[6]; Kempf, Dale ^[6]; Hol, Wim G. J. ^[1]; Merritt, Ethan A. ^[1]; Neckermann, Georg ^[7]; de Hostos, Eugenio L. ^[7] more »

Department of Biochemistry, University of Washington, Seattle, Washington 98195, United States
Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington 98109, United States
Department of Chemistry, University of Washington, Seattle, Washington 98195, United States
Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States
Portland VA Medical Center, Portland, Oregon 97239, United States
AbbVie, N. Chicago, Illinois 60064, United States
PATH, San Francisco, California 94102, United States
Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, United States
Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States, Department of Global Health, University of Washington, Seattle, Washington 98195, United States
Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington 98109, United States, Department of Global Health, University of Washington, Seattle, Washington 98195, United States

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Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-76SF00515

OSTI ID:: 1227228

Journal Information:: ACS Medicinal Chemistry Letters, Journal Name: ACS Medicinal Chemistry Letters Vol. 6 Journal Issue: 12; ISSN 1948-5875

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 29 works

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References (21)

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Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold Zhang, Zhongsheng; Ojo, Kayode K.; Vidadala, RamaSubbaRao ACS Medicinal Chemistry Letters, Vol. 5, Issue 1 https://doi.org/10.1021/ml400315s	journal	November 2013
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